In vivo studies of a platinum(II) metallointercalator

被引：36
作者：
Fisher, Dianne M. [1 ]
Fenton, Ronald R. [1 ]
Aldrich-Wright, Janice R. [2 ]
机构：
[1] Univ Sydney, Ctr Heavy Met Res, Sch Chem, Sydney, NSW 2006, Australia
[2] Univ Western Sydney, Sch Biomed & Hlth Sci, Penrith, NSW 1797, Australia
来源：
CHEMICAL COMMUNICATIONS | 2008年 / 43期
关键词：
D O I：
10.1039/b811723c
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An in vivo study for determining the toxicity and efficacy of [Pt(S,S-dach)(phen)Cl-2 center dot 1.5H(2)O center dot 0.5HCl (PHENSS) in female Specific Pathogen Free (SPF) Swiss nude mice bearing PC3 tumour xenografts revealed PHENSS to be non-toxic and effective in decreasing tumour growth.
引用
收藏
页码：5613 / 5615
页数：3
相关论文
共 26 条
[1]   Platinum-intercalator conjugates: From DNA-targeted cisplatin derivatives to adenine binding complexes as potential modulators of gene regulation [J].
Baruah, H ;
Barry, CG ;
Bierbach, U .
CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2004, 4 (15) :1537-1549
[2]  
Clark DL, 1999, CLIN CANCER RES, V5, P1161
[3]   Chiral platinum(II) metallointercalators with potent in vitro cytotoxic activity [J].
Fisher, Dianne M. ;
Bednarski, Patrick J. ;
Gruenert, Renate ;
Turner, Peter ;
Fenton, Ronald R. ;
Aldrich-Wright, Janice R. .
CHEMMEDCHEM, 2007, 2 (04) :488-495
[4]  
Fuertes M. A., 2002, Current Medicinal Chemistry - Anti-Cancer Agents, V2, P539
[5]  
GALE EF, 1972, MOL BASIS ANTIBIOTIC, P173
[6]   The synthesis and in vitro cytotoxicity of two trans-platinum complexes of heterocyclic amines [J].
Giannikopoulos, G ;
Teo, CL ;
Hall, MD ;
Fenton, RR ;
Hambley, TW .
AUSTRALIAN JOURNAL OF CHEMISTRY, 2003, 56 (07) :685-689
[7]   The influence of structure on the activity and toxicity of Pt anti-cancer drugs [J].
Hambley, TW .
COORDINATION CHEMISTRY REVIEWS, 1997, 166 :181-223
[8]   Tumour-inhibiting platinum complexes-state of the art and future perspectives [J].
Jakupec, MA ;
Galanski, M ;
Keppler, BK .
REVIEWS OF PHYSIOLOGY, BIOCHEMISTRY AND PHARMACOLOGY, VOL 146, 2003, 146 :1-53
[9]   New developments and approaches in the platinum arena [J].
Judson, I ;
Kelland, LR .
DRUGS, 2000, 59 (Suppl 4) :29-36
[10]   Preclinical perspectives on platinum resistance [J].
Kelland, LR .
DRUGS, 2000, 59 (Suppl 4) :1-8
123