Very low dose of flutamide in the treatment of hyperandrogenism

被引：7

作者：

Fulghesu, Anna Maria ^{[1
]}

Melis, Federica ^{[1
]}

Murru, Giulia ^{[2
]}

Canu, Elena ^{[1
]}

Melis, Gian Benedetto ^{[1
]}

机构：

[1] Univ Cagliari, Dept Obstet & Gynecol, Cagliari, Italy

[2] Univ Milan, Dept Obstet & Gynecol, Osped San Paolo, Milan, Italy

来源：

GYNECOLOGICAL ENDOCRINOLOGY | 2018年 / 34卷 / 05期

关键词：

Hirsutism; hormonal contraception; hyperandrogenism; flutamide; POLYCYSTIC-OVARY-SYNDROME; LONG-TERM; HIRSUTISM; HEPATOTOXICITY; WOMEN; THERAPY; SPIRONOLACTONE; PCOS; RISK;

D O I：

10.1080/09513590.2017.1397114

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Hyperandrogenism is a condition affecting 5-10% of adolescents. The aim of this study was to evaluate the efficacy of very low dose of flutamide in the treatment of hyperandrogenism in adolescence. One hundred and fifty-eight patients, presenting severe acne and/or hirsutism, received 62.5mg/day of flutamide+ethinylestradiol+gestodene for 18months. The patients were subjected to assessments of hepatic enzymes levels. Thirty subjects treated with drospirenone+ethinylestradiol represented the control group. After 18months of treatment, it was obtained a decrease of hirsutism (-39.9%), an almost recovery of acne (98% of patients) with better results of those obtained in control group. Only one case of light hypertransaminasemia was recorded, regressed spontaneously. Very low dose of flutamide was successful and safe and in the treatment of hyperandrogenism in adolescence.

引用

页码：394 / 398

页数：5

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