1-Azadienes in cycloaddition and multicomponent reactions towards N-heterocycles

被引：195
作者：
Groenendaal, Bas [1 ]
Ruijter, Eelco [1 ]
Orru, Romano V. A. [1 ]
机构：
[1] Vrije Univ Amsterdam, Dept Chem & Pharmaceut Sci, NL-1081 HV Amsterdam, Netherlands
来源：
CHEMICAL COMMUNICATIONS | 2008年 / 43期
关键词：
D O I：
10.1039/b809206k
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
1-Azadienes are versatile building blocks for the efficient construction of various N-heterocycles. Depending on the substitution pattern and reaction partner, they may participate in a range of different reactions. An overview of recent methods for the generation of 1-azadienes is presented, as well as their application in cycloaddition, electrocyclization, and multicomponent reactions. Considering the broad range of reactivities and resulting heterocyclic scaffold structures, 1-azadienes are very useful reactive intermediates for the development of modular reaction sequences in diversity-oriented synthesis.
引用
收藏
页码：5474 / 5489
页数：16
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