Adipose tissue heterogeneity: Implication of depot differences in adipose tissue for obesity complications

被引：588
作者：
Lee, Mi-Jeong [1 ]
Wu, Yuanyuan [1 ]
Fried, Susan K. [1 ]
机构：
[1] Boston Univ, Sch Med, Dept Med, Sect Endocrinol Diabet & Nutr, Boston, MA 02118 USA
来源：
MOLECULAR ASPECTS OF MEDICINE | 2013年 / 34卷 / 01期
关键词：
BODY-FAT DISTRIBUTION; MESSENGER-RNA EXPRESSION; TYPE-2; DIABETES-MELLITUS; INSULIN-RESISTANCE; IN-VIVO; VISCERAL FAT; REGIONAL DIFFERENCES; RISK-FACTORS; SUBCUTANEOUS ADIPOCYTES; METABOLIC COMPLICATIONS;
D O I：
10.1016/j.mam.2012.10.001
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Obesity, defined as excess fat mass, increases risks for multiple metabolic diseases, such as type 2 diabetes, cardiovascular disease and several types of cancer. Over and above fat mass per se, the pattern of fat distribution, android or truncal as compared to gynoid or peripheral, has a profound influence on systemic metabolism and hence risk for metabolic diseases. Increases in upper body adipose tissue (visceral and abdominal subcutaneous) confer an independent risk, while the quantity of gluteofemoral adipose tissue is protective. Variations in the capacity of different depots to store and release fatty acids and to produce adipokines are important determinants of fat distribution and its metabolic consequences. Depot differences in cellular composition and physiology, including innervation and blood flow, likely influence their phenotypic properties. A number of lines of evidence also support the idea that adipocytes from different anatomical depots are intrinsically different as a result of genetic or developmental events. In this chapter, we will review the phenotypic characteristics of different adipose depots and mechanisms that link their depot-specific biology to metabolic complications in men and women. (C) 2012 Elsevier Ltd. All rights reserved.
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页数：11
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共 108 条
[1]   Harmonizing the Metabolic Syndrome A Joint Interim Statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity [J].
Alberti, K. G. M. M. ;
Eckel, Robert H. ;
Grundy, Scott M. ;
Zimmet, Paul Z. ;
Cleeman, James I. ;
Donato, Karen A. ;
Fruchart, Jean-Charles ;
James, W. Philip T. ;
Loria, Catherine M. ;
Smith, Sidney C., Jr. .
CIRCULATION, 2009, 120 (16) :1640-1645
[2]   Androgens and obesity [J].
Allan, Carolyn A. ;
McLachlan, Robert I. .
CURRENT OPINION IN ENDOCRINOLOGY DIABETES AND OBESITY, 2010, 17 (03) :224-232
[3]   Adipocyte Hypertrophy, Fatty Liver and Metabolic Risk Factors in South Asians: The Molecular Study of Health and Risk in Ethnic Groups (mol-SHARE) [J].
Anand, Sonia S. ;
Tarnopolsky, Mark A. ;
Rashid, Shirya ;
Schulze, Karleen M. ;
Desai, Dipika ;
Mente, Andrew ;
Rao, Sandy ;
Yusuf, Salim ;
Gerstein, Hertzel C. ;
Sharma, Arya M. .
PLOS ONE, 2011, 6 (07)
[4]   Adipose macrophage infiltration is associated with insulin resistance and vascular endothelial dysfunction in obese subjects [J].
Apovian, Caroline M. ;
Bigornia, Sherman ;
Mott, Melanie ;
Meyers, Melissa R. ;
Ulloor, Jagadish ;
Gagua, Manana ;
McDonnell, Marie ;
Hess, Donald ;
Joseph, Lija ;
Gokce, Noyan .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2008, 28 (09) :1654-1659
[5]   DIFFERENCES IN LIPOLYSIS BETWEEN HUMAN SUBCUTANEOUS AND OMENTAL ADIPOSE TISSUES [J].
ARNER, P .
ANNALS OF MEDICINE, 1995, 27 (04) :435-438
[6]   Adipose tissue distribution in relation to insulin resistance in type 2 diabetes mellitus [J].
Azuma, Koichiro ;
Heilbronn, Leonie K. ;
Albu, Jeanine B. ;
Smith, Steven R. ;
Ravussin, Eric ;
Kelley, David E. .
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2007, 293 (01) :E435-E442
[7]   Sympathetic and sensory innervation of white adipose tissue [J].
Bartness, Timothy J. ;
Song, C. K. .
JOURNAL OF LIPID RESEARCH, 2007, 48 (08) :1655-1672
[8]   Surgical removal of visceral fat reverses hepatic insulin resistance [J].
Barzilai, N ;
She, L ;
Liu, BQ ;
Vuguin, P ;
Cohen, P ;
Wang, JL ;
Rossetti, L .
DIABETES, 1999, 48 (01) :94-98
[9]   Mitogen-activated protein kinases, inhibitory-κB kinase, and insulin signaling in human omental versus subcutaneous adipose tissue in obesity [J].
Bashan, Nava ;
Dorfman, Karina ;
Tarnovscki, Tanya ;
Harman-Boehm, Ilana ;
Liberty, Idit F. ;
Blueher, Matthias ;
Ovadia, Shira ;
Maymon-Zilberstein, Tali ;
Potashnik, Ruth ;
Stumvoll, Michael ;
Avinoach, Eliezer ;
Rudich, Assaf .
ENDOCRINOLOGY, 2007, 148 (06) :2955-2962
[10]   Omentin plasma levels and gene expression are decreased in obesity [J].
Batista, Celia M. de Souza ;
Yang, Rong-Ze ;
Lee, Mi-Jeong ;
Glynn, Nicole M. ;
Yu, Dao-Zhan ;
Pray, Jessica ;
Ndubuizu, Kelechi ;
Patil, Susheel ;
Schwartz, Alan ;
Kligman, Mark ;
Fried, Susan K. ;
Gong, Da-Wei ;
Shuldiner, Alan R. ;
Pollin, Toni I. ;
McLenithan, John C. .
DIABETES, 2007, 56 (06) :1655-1661
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