Changing the Tumor Microenvironment: New Strategies for Immunotherapy

被引：22

作者：

Berraondo, Pedro ^{[1
]}

Umansky, Viktor ^{[2
,3
]}

Melero, Ignacio ^{[1
]}

机构：

[1] Univ Navarra, Univ Navarra Clin, Ctr Appl Med Res, Div Hepatol & Gene Therapy, Navarra, Spain

[2] German Canc Res Ctr, Skin Canc Unit, D-6900 Heidelberg, Germany

[3] Univ Hosp Mannheim, Heidelberg, Germany

来源：

CANCER RESEARCH | 2012年 / 72卷 / 20期

关键词：

ADVANCED MELANOMA PATIENTS; CANCER; ANTIBODY; IPILIMUMAB; EXPRESSION; SAFETY;

D O I：

10.1158/0008-5472.CAN-12-1952

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Solid tumors are composed of malignant cells surrounded by a tumor-conditioned stroma that contains extracellular matrix and a variety of nonmalignant populations, including myeloid cells, lymphocytes, fibroblasts, and endothelial cells. These stromal elements form a local immunoregulatory network that must be overcome to achieve eradication of established tumors by immunotherapy. On March 21-22, 2012, a symposium was held in Pamplona, Spain, to share the recent advances regarding the molecules and cells that create and sustain this immune-hostile tumor microenvironment. Excellent targets for immunotherapeutic intervention were identified, and a number of therapeutic strategies under translation from mouse to human were presented. Cancer Res; 72(20); 5159-64. (C)2012 AACR.

引用

页码：5159 / 5164

页数：6

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