Fibroblast activation proteins-α suppress tumor immunity by regulating T cells and tumor-associated macrophages

被引：22

作者：

Hou, Chun Mei ^{[1
]}

Qu, Xue Mei ^{[1
]}

Zhang, Jian ^{[1
]}

Ding, Ting Ting ^{[1
]}

Han, Wei ^{[3
]}

Ji, Guang Chuan ^{[1
]}

Zhong, Zhao Hua ^{[4
]}

Chen, He ^{[1
,2
]}

Zhang, FengMin ^{[4
]}

机构：

[1] Harbin Med Univ, Basic Med Coll, Dept Forens, 157 Baojian Rd, Harbin 150086, Heilongjiang, Peoples R China

[2] Harbin Med Univ, Basic Med Coll, Dept Pathol, Harbin, Heilongjiang, Peoples R China

[3] Harbin Med Univ, Hosp 1, Dept Pathol, Harbin, Heilongjiang, Peoples R China

[4] Harbin Med Univ, Basic Med Coll, Dept Microbiol, 157 Baojian Rd, Harbin 150086, Heilongjiang, Peoples R China

来源：

EXPERIMENTAL AND MOLECULAR PATHOLOGY | 2018年 / 104卷 / 01期

关键词：

Fibroblast activation protein-alpha (FAP alpha); Epithelial ovarian cancer (EOC); Regulatory T cells (Treg); CD4+CD25+Tregs; Foxp3; ANTITUMOR IMMUNITY; MICROENVIRONMENT; EXPRESSION; POLARIZATION; IMMUNOSUPPRESSION; RECRUITMENT; PLASTICITY; DIVERSITY;

D O I：

10.1016/j.yexmp.2017.12.003

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Fibroblast activation protein-alpha (FAP alpha) is a type-II cell-surface-bound integral transmembrane serine protease and selectively overexpressed by tumor-associated stromal fibroblasts (TAFs), which are the main components in the tumor microenvironment, in > 90% of malignant epithelial carcinomas. FAPa regulates the immunosuppression of tumor cells in the tumor microenvironment. Regulatory T cells (Tregs) and tumor-associated macrophages (TAMs) are the major immunosuppressive cells in the tumor microenvironment. However, the effect of FAP alpha on Tregs and TAMs is unknown. The non-enzymatic function of FAP alpha on Treg and TAM was investigated. In this study, we confirm that FAP alpha can promote the generation of Tregs and TAMs, which suggests that FAP alpha plays a immunosuppressive role in the tumor microenvironment and provides evidence for FAP alpha as a potent immunotherapeutic target for cancer.

引用

页码：29 / 37

页数：9