Strategies for the construction of γ-spirocyclic butenolides in natural product synthesis

被引：42
作者：
Mandal, Sudip [1 ]
Thirupathi, Barla [1 ]
机构：
[1] Indian Inst Sci Educ & Res Berhampur, Dept Chem Sci, Transit Campus,Govt ITI Bldg,NH 59,Engn Sch Rd, Berhampur 760010, Odisha, India
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2020年 / 18卷 / 28期
关键词：
VINYLOGOUS MANNICH REACTIONS; ANTI-TUMOR ANTIBIOTICS; CYTOTOXIC STYRYL-LACTONES; RECEPTOR ANTAGONIST; ASYMMETRIC-SYNTHESIS; ABYSSOMICIN-C; ABSOLUTE STEREOCHEMISTRY; ALKALOIDS RUGULOVASINE; STREPTOMYCES SP-NR0489; SELECTIVE SYNTHESIS;
D O I：
10.1039/d0ob00954g
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Over the last four decades, a number of gamma-spirocyclic butenolide containing natural products, drugs, and medicinally useful synthetic compounds have been reported. In this review, we discuss diverse chemical approaches to synthesize gamma-spiro butenolides and their application towards natural product synthesis. The collective perception of various methods may allow superior approaches capable of delivering efficient synthetic approaches to obtain gamma-spiro butenolide comprising natural products and their hybrid analogues for further drug discovery and development.
引用
收藏
页码：5287 / 5314
页数：28
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