Transcriptional and Epigenetic Regulation of Microglia in Health and Disease

被引：70
|
作者：
Yeh, Hana [1 ,2 ]
Ikezu, Tsuneya [2 ,3 ]
机构：
[1] Boston Univ, Sch Med, Grad Program Neurosci, Boston, MA 02118 USA
[2] Boston Univ, Dept Pharmacol & Expt Therapeut, Sch Med, Boston, MA 02118 USA
[3] Boston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USA
来源：
TRENDS IN MOLECULAR MEDICINE | 2019年 / 25卷 / 02期
关键词：
PLURIPOTENT STEM-CELLS; GENE-EXPRESSION; LANGERHANS CELLS; ADULT MICROGLIA; YOLK-SAC; PU.1; MOUSE; MICE; REVEALS; ABNORMALITIES;
D O I：
10.1016/j.molmed.2018.11.004
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Microglia are the resident immune cells that maintain brain homeostasis and contribute to neurodegenerative disorders. Recent studies of microglia at transcriptomic and epigenetic levels revealed specific molecular pathways that regulate microglia development, maturation, and reactive states. The transcription factor PU.1 plays a key role in regulating several microglial functions. Environmental factors such as microbiota, early life stress, and maternal immune activation can dysregulate PU.1 and innate immune response. This review discusses the epigenetic regulation of key transcriptional factors in human and murine microglia, highlighting their networks for shaping the microglial function. PU.1 and other microglia-specific transcriptional factors can be further studied to determine their therapeutic applications in neurologic disorders.
引用
收藏
页码：96 / 111
页数：16
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