Transcriptional and Epigenetic Regulation of Microglia in Health and Disease

被引：70
|
作者：
Yeh, Hana [1 ,2 ]
Ikezu, Tsuneya [2 ,3 ]
机构：
[1] Boston Univ, Sch Med, Grad Program Neurosci, Boston, MA 02118 USA
[2] Boston Univ, Dept Pharmacol & Expt Therapeut, Sch Med, Boston, MA 02118 USA
[3] Boston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USA
来源：
TRENDS IN MOLECULAR MEDICINE | 2019年 / 25卷 / 02期
关键词：
PLURIPOTENT STEM-CELLS; GENE-EXPRESSION; LANGERHANS CELLS; ADULT MICROGLIA; YOLK-SAC; PU.1; MOUSE; MICE; REVEALS; ABNORMALITIES;
D O I：
10.1016/j.molmed.2018.11.004
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Microglia are the resident immune cells that maintain brain homeostasis and contribute to neurodegenerative disorders. Recent studies of microglia at transcriptomic and epigenetic levels revealed specific molecular pathways that regulate microglia development, maturation, and reactive states. The transcription factor PU.1 plays a key role in regulating several microglial functions. Environmental factors such as microbiota, early life stress, and maternal immune activation can dysregulate PU.1 and innate immune response. This review discusses the epigenetic regulation of key transcriptional factors in human and murine microglia, highlighting their networks for shaping the microglial function. PU.1 and other microglia-specific transcriptional factors can be further studied to determine their therapeutic applications in neurologic disorders.
引用
收藏
页码：96 / 111
页数：16
相关论文
共 50 条
  • [21] Transcriptional and epigenetic regulation of human microRNAs
    Wang, Zifeng
    Yao, Hong
    Lin, Sheng
    Zhu, Xiao
    Shen, Zan
    Lu, Gang
    Poon, Wai Sang
    Xie, Dan
    Lin, Marie Chia-mi
    Kung, Hsiang-fu
    CANCER LETTERS, 2013, 331 (01) : 1 - 10
  • [22] Transcriptional and epigenetic regulation in human islets
    Nuria C. Bramswig
    Klaus H. Kaestner
    Diabetologia, 2014, 57 : 451 - 454
  • [23] Transcriptional and Epigenetic Regulation of Autophagy in Plants
    Yang, Chao
    Luo, Min
    Zhuang, Xiaohong
    Li, Faqiang
    Gao, Caiji
    TRENDS IN GENETICS, 2020, 36 (09) : 676 - 688
  • [24] Epigenetic and transcriptional regulation of osteoclast differentiation
    Kurotaki, Daisuke
    Yoshida, Haruka
    Tamura, Tomohiko
    BONE, 2020, 138
  • [25] Transcriptional and epigenetic regulation of macrophages in atherosclerosis
    Kuznetsova, Tatyana
    Prange, Koen H. M.
    Glass, Christopher K.
    de Winther, Menno P. J.
    NATURE REVIEWS CARDIOLOGY, 2020, 17 (04) : 216 - 228
  • [26] Transcriptional and Epigenetic Regulation of Cardiac Electrophysiology
    Jesus Jimenez
    Stacey L. Rentschler
    Pediatric Cardiology, 2019, 40 : 1325 - 1330
  • [27] Transcriptional and epigenetic regulation of autophagy in aging
    Lapierre, Louis R.
    Kumsta, Caroline
    Sandri, Marco
    Ballabio, Andrea
    Hansen, Malene
    AUTOPHAGY, 2015, 11 (06) : 867 - 880
  • [28] Environmental Regulation of Epigenetic and Transcriptional Landscapes
    Meaney, Michael
    NEUROPSYCHOPHARMACOLOGY, 2016, 41 : S18 - S19
  • [29] TRANSCRIPTIONAL AND EPIGENETIC CONTROL OF MICROGLIA POLARIZATION INTO INFLAMMATORY OR ALTERNATIVE PHENOTYPE
    Kaminska, B.
    Dabrowski, M.
    Maleszewska, M.
    Steranka, A.
    Smiech, M.
    Ellert-Miklaszewska, A.
    GLIA, 2013, 61 : S185 - S185
  • [30] Epigenetic Regulation of Kupffer Cell Function in Health and Disease
    Bennett, Hunter
    Troutman, Ty D.
    Sakai, Mashito
    Glass, Christopher K.
    FRONTIERS IN IMMUNOLOGY, 2021, 11
12345