SF3B1 Mutations Induce Oncogenic IRAK4 Isoforms and Activate Targetable Innate Immune Pathways in MDS and AML

被引：16

作者：

Choudhary, Gaurav S. ^{[1
]}

Smith, Molly A. ^{[2
]}

Pellagatti, Andrea ^{[3
]}

Bhagat, Tushar D. ^{[1
]}

Gordon, Shanisha ^{[1
]}

Pandey, Sanjay ^{[4
]}

Shah, Nishi ^{[4
]}

Aluri, Srinivas ^{[4
]}

Booher, Robert N. ^{[5
]}

Ramachandra, Murali ^{[6
]}

Samson, Maria Elena ^{[5
]}

Pradhan, Kith ^{[1
]}

Bowman, Teresa V. ^{[4
]}

Pillai, Manoj M. ^{[7
]}

Guha, Chandan ^{[4
]}

Wickrema, Amittha ^{[8
]}

Will, Britta ^{[1
]}

Shastri, Aditi ^{[9
]}

Steidl, Ulrich G. ^{[10
]}

Boultwood, Jacqueline ^{[3
]}

Starczynowski, Daniel T. ^{[11
]}

Verma, Amit ^{[1
]}

机构：

[1] Montefiore Med Ctr, Albert Einstein Coll Med, Dept Oncol, Bronx, NY 10467 USA

[2] Cincinnati Childrens Hosp Med Ctr, Div Expt Hematol & Canc Biol, Cincinnati, OH 45229 USA

[3] Univ Oxford, Oxford, England

[4] Montefiore Med Ctr, Albert Einstein Coll Med, Bronx, NY 10467 USA

[5] Curis Inc, Lexington, MA USA

[6] Aurigene Discovery Technol Ltd, Bangalore, Karnataka, India

[7] Yale Univ, Sch Med, Dept Internal Med, Sect Hematol, New Haven, CT 06510 USA

[8] Univ Chicago, Chicago, IL 60637 USA

[9] Montefiore Med Ctr, Albert Einstein Coll Med, Dept Hematol & Oncol, Bronx, NY 10467 USA

[10] Albert Einstein Coll Med, Dept Oncol, Bronx, NY 10467 USA

[11] Cincinnati Childrens Hosp Med Ctr, Cincinnati, OH 45229 USA

来源：

BLOOD | 2019年 / 134卷

关键词：

D O I：

10.1182/blood-2019-124458

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

4224

引用

页数：3