Molecular Phenotype of Primary Mammary Tumours and Distant Metastases in Female Dogs and Cats

被引：12

作者：

Beha, G. ^{[1
]}

Muscatello, L. V. ^{[1
]}

Brunetti, B. ^{[1
]}

Asproni, P. ^{[2
]}

Millanta, F. ^{[2
]}

Poli, A. ^{[2
]}

Benazzi, C. ^{[1
]}

Sarli, G. ^{[1
]}

机构：

[1] Univ Bologna, Dept Vet Med Sci, I-40126 Bologna, Italy

[2] Univ Pisa, Sch Vet Med, Dept Anim Pathol, I-56100 Pisa, Italy

来源：

JOURNAL OF COMPARATIVE PATHOLOGY | 2014年 / 150卷 / 2-3期

关键词：

cat; distant metastasis; dog; mammary tumour phenotype; EXPRESSION; CARCINOMAS;

D O I：

10.1016/j.jcpa.2013.07.011

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Distant metastases represent a major step in the progression and fatal outcome of canine and feline mammary carcinomas. Recent studies have characterized the molecular phenotypes of mammary tumours and provided information on molecules that may allow targeted therapy in sites from which the tumours may not readily be surgically resected. Molecular phenotypes were determined immunohistochemically in three feline and two canine cases of mammary neoplasia, each presenting with multiple distant metastases. These tumours and their metastases often overexpressed the c-erbB-2 phenotype. A basal-like phenotype was found in the distant metastases from two cases. These findings suggest that canine and feline mammary tumours with distant metastases may be amenable to novel targeted therapies. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：194 / 197

页数：4

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