Target-matched therapies in patients with advanced cervical cancers harboring PIK3CA mutations and/or PTEN loss.

被引:0
|
作者
Hou, Ming-Mo [1 ]
Liu, Xiaochun [1 ]
Piha-Paul, Sarina A. [1 ]
Janku, Filip [1 ]
Wheler, Jennifer [1 ]
Naing, Aung [1 ]
Bodurka, Diane [1 ]
Schmeler, Kathleen [1 ]
Lu, Karen [1 ]
Zinner, Ralph [1 ]
Hong, David [1 ]
Meric-Bernstam, Funda [1 ]
Kurzrock, Razelle [2 ]
Fu, Siqing [1 ]
机构
[1] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA
[2] UC San Diego Moores Canc Ctr, La Jolla, CA USA
关键词
D O I
10.1158/1535-7163.TARG-13-B191
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
B191
引用
收藏
页数:1
相关论文
共 50 条
  • [21] PIK3CA and APC mutations are synergistic in the development of intestinal cancers
    D A Deming
    A A Leystra
    L Nettekoven
    C Sievers
    D Miller
    M Middlebrooks
    L Clipson
    D Albrecht
    J Bacher
    M K Washington
    J Weichert
    R B Halberg
    Oncogene, 2014, 33 : 2245 - 2254
  • [22] PIK3CA and APC mutations are synergistic in the development of intestinal cancers
    Deming, D. A.
    Leystra, A. A.
    Nettekoven, L.
    Sievers, C.
    Miller, D.
    Middlebrooks, M.
    Clipson, L.
    Albrecht, D.
    Bacher, J.
    Washington, M. K.
    Weichert, J.
    Halberg, R. B.
    ONCOGENE, 2014, 33 (17) : 2245 - 2254
  • [23] High frequency of mutations of the PIK3CA gene in human cancers
    Samuels, Y
    Wang, ZH
    Bardelli, A
    Silliman, N
    Ptak, J
    Szabo, S
    Yan, H
    Gazdar, A
    Powell, DM
    Riggins, GJ
    Willson, JKV
    Markowitz, S
    Kinzler, KW
    Vogelstein, B
    Velculescu, VE
    SCIENCE, 2004, 304 (5670) : 554 - 554
  • [24] PIK3CA mutations in plasma circulating tumor DNA predict survival and treatment outcomes in patients with advanced cancers
    Dumbrava, E. E.
    Call, S. G.
    Huang, H. J.
    Stuckett, A. L.
    Madwani, K.
    Adat, A.
    Hong, D. S.
    Piha-Paul, S. A.
    Subbiah, V.
    Karp, D. D.
    Fu, S.
    Naing, A.
    Tsimberidou, A. M.
    Moulder, S. L.
    Koenig, K. H.
    Barcenas, C. H.
    Kee, B. K.
    Fogelman, D. R.
    Kopetz, E. S.
    Meric-Bernstam, F.
    Janku, F.
    ESMO OPEN, 2021, 6 (05)
  • [25] Impact of PIK3CA gain and PTEN loss on mantle cell lymphoma biology and sensitivity to targeted therapies
    Bettazova, Nardjas
    Senavova, Jana
    Kupcova, Kristyna
    Sovilj, Dana
    Rajmonova, Anezka
    Andera, Ladislav
    Svobodova, Karla
    Berkova, Adela
    Zemanova, Zuzana
    Daumova, Lenka
    Herman, Vaclav
    Davis, R. Eric
    Trneny, Marek
    Klener, Pavel
    Havranek, Ondrej
    Dolnikova, Alexandra
    BLOOD ADVANCES, 2024, 8 (20) : 5279 - 5289
  • [26] PIK3CA Mutations in Patients with Advanced Cancers Treated with PI3K/AKT/mTOR Axis Inhibitors
    Janku, Filip
    Tsimberidou, Apostolia M.
    Garrido-Laguna, Ignacio
    Wang, Xuemei
    Luthra, Rajyalakshmi
    Hong, David S.
    Naing, Aung
    Falchook, Gerald S.
    Moroney, John W.
    Piha-Paul, Sarina A.
    Wheler, Jennifer J.
    Moulder, Stacy L.
    Fu, Siqing
    Kurzrock, Razelle
    MOLECULAR CANCER THERAPEUTICS, 2011, 10 (03) : 558 - 565
  • [27] BRAF, PIK3CA, and KRAS mutations and loss of PTEN expression impair response to EGFR-targeted therapies in metastatic colorectal cancer
    Di Nicolantonio, Federica
    Sartore-Bianchi, Andrea
    Molinari, Francesca
    Martini, Miriam
    Saletti, Piercarlo
    Mazzucchelli, Luca
    Veronese, Silvio
    Moroni, Mauro
    Nichelatti, Michele
    Frattini, Milo
    Siena, Salvatore
    Bardelli, Alberto
    CANCER RESEARCH, 2009, 69
  • [28] mTOR Co-Targeting in Cetuximab Resistance in Head and Neck Cancers Harboring PIK3CA and RAS Mutations
    Wang, Zhiyong
    Martin, Daniel
    Molinolo, Alfredo A.
    Patel, Vyomesh
    Iglesias-Bartolome, Ramiro
    Degese, Maria Sol
    Vitale-Cross, Lynn
    Chen, Qianming
    Gutkind, J. Silvio
    JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2014, 106 (09):
  • [29] PIK3CA gene mutations and amplifications in uterine cancers, identified by methods that avoid confounding by PIK3CA pseudogene sequences
    Miyake, Takahito
    Yoshino, Kiyoshi
    Enomoto, Takayuki
    Takata, Tomomi
    Ugaki, Hiromi
    Kim, Ayako
    Fujiwara, Kazuko
    Miyatake, Takashi
    Fujita, Masami
    Kimura, Tadashi
    CANCER LETTERS, 2008, 261 (01) : 120 - 126
  • [30] PIK3CA MUTATIONS AND LOSS OF PTEN EXPRESSION IN CIRCULATING TUMOR CELLS (CTCS) IN PATIENTS WITH METASTATIC BREAST CANCER (MBC)
    Lozano Mejorada, R.
    Matos, I.
    Marcos, R. A.
    Alfonso, S.
    Guillen, C.
    Noguerido, A.
    Rua, O.
    Vidal, R.
    Hernandez, M. A.
    Garcia, J. L.
    Gomez Bernal, A.
    Rodriguez, C. A.
    Cruz Hernandez, J. J.
    ANNALS OF ONCOLOGY, 2014, 25