Antitumor effect of poly(ethylene glycol)modified fullerene

被引：49
|
作者：
Tabata, Y [1 ]
Murakami, Y [1 ]
Ikada, Y [1 ]
机构：
[1] KYOTO UNIV,BIOMED ENGN RES CTR,SAKYO KU,KYOTO 606,JAPAN
来源：
FULLERENE SCIENCE AND TECHNOLOGY | 1997年 / 5卷 / 05期
关键词：
D O I：
10.1080/15363839708013312
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
Water-insoluble fullerene (C-60) was chemically modified with poly(ethylene glycol) (PEG) to solubilize it in water. The C-60-PEG conjugates, upon injecting intravenously, were accumulated in the tumor to a greater extent than in the normal tissue and exhibited prolonged C-60 retention at the tumor tissue. Conjugate injection followed by light irradiation significantly suppressed the volume increase of tumor. We conclude that the PEG-modified C-60 has a high potentiality as a drug of photodynamic tumor therapy.
引用
收藏
页码：989 / 1007
页数：19
相关论文
共 50 条
  • [21] Spectral Properties of a Benzothiazole Dye Modified with Poly(Ethylene Glycol)
    A. A. Maskevich
    Journal of Applied Spectroscopy, 2022, 88 : 1125 - 1130
  • [22] Preparation and properties of modified poly(vinyl alcohol)/poly(ethylene glycol) composites
    Fan, Wenru
    Mao, Qing
    Fei, Guoxia
    Xia, Hesheng
    Gaofenzi Cailiao Kexue Yu Gongcheng/Polymeric Materials Science and Engineering, 2014, 30 (02): : 115 - 120
  • [23] Poly(vinyl chloride) Asymmetric Membrane Modified with Poly (ethylene glycol): Effect of Additive Concentration on the Morphology and Performance
    Roy, K. J.
    Anjali, T. V.
    Sujith, A.
    POLYMER-PLASTICS TECHNOLOGY AND ENGINEERING, 2017, 56 (09) : 1017 - 1025
  • [24] The effect of poly(ethylene glycol) on the properties of poly (lactic acid)/silane-modified bacterial cellulose nanocomposites
    Sadeghi, Raha
    Daneshfar, Zahra
    POLYMER-PLASTICS TECHNOLOGY AND MATERIALS, 2024, 63 (09): : 1227 - 1238
  • [25] Effect of poly(ethylene glycol) on the solid-state polymerization of poly(ethylene tereplithalate)
    Gowd, EB
    Ramesh, C
    POLYMER INTERNATIONAL, 2006, 55 (03) : 340 - 345
  • [26] Antitumor properties of irinotecan-containing nanoparticles prepared using poly(DL-lactic acid) and poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol)
    Onishi, H
    Machida, Y
    Machida, Y
    BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2003, 26 (01) : 116 - 119
  • [27] ANTITUMOR-ACTIVITY OF DOXORUBICIN ENCAPSULATED IN POLY(ETHYLENE GLYCOL)-COATED LIPOSOMES
    HOSODA, J
    UNEZAKI, S
    MARUYAMA, K
    TSUCHIYA, S
    IWATSURU, M
    BIOLOGICAL & PHARMACEUTICAL BULLETIN, 1995, 18 (09) : 1234 - 1237
  • [28] Synthesis of monomethoxy poly(ethylene glycol) without diol poly(ethylene glycol)
    Zhang, Jing
    Zhao, Yong-Jiang
    Su, Zhi-Guo
    Ma, Guang-Hui
    JOURNAL OF APPLIED POLYMER SCIENCE, 2007, 105 (06) : 3782 - 3786
  • [29] Effect of thermal treatment of poly(ethylene glycol) modified with europium acetylacetonate on its chromatographic properties
    Slizhov, Yu.G.
    Gavrilenko, M.A.
    Zhurnal Fizicheskoj Khimii, 2001, 75 (06): : 1120 - 1122
  • [30] Effect of thermal treatment of poly(ethylene glycol) modified with europium acetylacetonate on its chromatographic properties
    Slizhov, YG
    Gavrilenko, MA
    RUSSIAN JOURNAL OF PHYSICAL CHEMISTRY, 2001, 75 (06): : 1012 - 1013
12345