Antitumor effect of poly(ethylene glycol)modified fullerene

被引：49

作者：

Tabata, Y ^{[1
]}

Murakami, Y ^{[1
]}

Ikada, Y ^{[1
]}

机构：

[1] KYOTO UNIV,BIOMED ENGN RES CTR,SAKYO KU,KYOTO 606,JAPAN

来源：

FULLERENE SCIENCE AND TECHNOLOGY | 1997年 / 5卷 / 05期

关键词：

D O I：

10.1080/15363839708013312

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Water-insoluble fullerene (C-60) was chemically modified with poly(ethylene glycol) (PEG) to solubilize it in water. The C-60-PEG conjugates, upon injecting intravenously, were accumulated in the tumor to a greater extent than in the normal tissue and exhibited prolonged C-60 retention at the tumor tissue. Conjugate injection followed by light irradiation significantly suppressed the volume increase of tumor. We conclude that the PEG-modified C-60 has a high potentiality as a drug of photodynamic tumor therapy.

引用

页码：989 / 1007

页数：19

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