7α,20-epoxy-ent-kauranoids from Isodon parvifolius

被引：20

作者：

Li, LM

Li, GY

Huang, SX

Li, SH

Zhou, Y

Xiao, WL

Lou, LG

Ding, LS

Sun, HD ^{[1
]}

机构：

[1] Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China

[2] Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China

[3] Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Peoples R China

[4] Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200032, Peoples R China

[5] Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai 200032, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2006年 / 69卷 / 04期

关键词：

D O I：

10.1021/np0600200

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Nine new 7 alpha, 20-epoxy-ent-kaurane diterpenoids, parvifolines C- K (1-9), together with 12 known analogues, rabdoternin G ( 10), adenolin E ( 11), lasiodonin ( 12), lushanrubescensin F ( 13), parvifoliside ( 14), effusanin A ( 15), effusanin B ( 16), effusanin E ( 17), taibaihenryiin A ( 18), shikokianin ( 19), maoyecrystal J ( 20), and the acetonide of lasiodonin ( 21), were isolated from the leaves of Isodon parvifolius. The structures of compounds 1-9 were determined on the basis of spectroscopic methods including extensive 1D and 2D NMR analysis. The new diterpenoids (1-9) and lasiodonin ( 12) were evaluated for their inhibitory activity against A549, HT-29, and K562 cell lines.

引用

页码：645 / 649

页数：5