7α,20-epoxy-ent-kauranoids from Isodon parvifolius

被引：19

作者：

Li, LM

Li, GY

Huang, SX

Li, SH

Zhou, Y

Xiao, WL

Lou, LG

Ding, LS

Sun, HD ^{[1
]}

机构：

[1] Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China

[2] Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China

[3] Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Peoples R China

[4] Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200032, Peoples R China

[5] Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai 200032, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2006年 / 69卷 / 04期

关键词：

D O I：

10.1021/np0600200

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Nine new 7 alpha, 20-epoxy-ent-kaurane diterpenoids, parvifolines C- K (1-9), together with 12 known analogues, rabdoternin G ( 10), adenolin E ( 11), lasiodonin ( 12), lushanrubescensin F ( 13), parvifoliside ( 14), effusanin A ( 15), effusanin B ( 16), effusanin E ( 17), taibaihenryiin A ( 18), shikokianin ( 19), maoyecrystal J ( 20), and the acetonide of lasiodonin ( 21), were isolated from the leaves of Isodon parvifolius. The structures of compounds 1-9 were determined on the basis of spectroscopic methods including extensive 1D and 2D NMR analysis. The new diterpenoids (1-9) and lasiodonin ( 12) were evaluated for their inhibitory activity against A549, HT-29, and K562 cell lines.

引用

页码：645 / 649

页数：5

共 22 条

[1]

Bai SP, 2004, J CHEM RES, P384

[2] STRUCTURES OF EFFUSANINS, ANTI-BACTERIAL DITERPENOIDS FROM RABDOSIA-EFFUSA [J].

FUJITA, T ;

TAKEDA, Y ;

SHINGU, T ;

UENO, A .

CHEMISTRY LETTERS, 1980, (12) :1635-1638

[3]

GUO Y-W, 1990, Acta Botanica Sinica, V32, P707

[4]

GUO Y-W, 1991, Acta Botanica Sinica, V33, P722

[5]

GUO YW, 1991, CHINESE CHEM LETT, V2, P377

[6]

GUO YW, 1990, ZHONGGUO ZHONGYAO ZA, V15, P37

[7]

GUO YW, 1992, CHINESE CHEM LETT, V3, P633

[8] An asymmetric ent-kauranoid dimer from Isodon rubescens var. lushanensis [J].

Han, QB ;

Lu, Y ;

Wu, L ;

He, ZD ;

Qiao, CF ;

Xu, HX ;

Zheng, QT ;

Sun, HD .

TETRAHEDRON LETTERS, 2005, 46 (32) :5373-5375

[9] Ent-kauranoids from Isodon rubescens var. taihangensis [J].

Han, QB ;

Li, RT ;

Li, ML ;

Mou, YK ;

Tian, QE ;

Li, SW ;

Sun, HD .

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2005, 7 (01) :31-36

[10]

Han QB, 2003, CHEM PHARM BULL, V51, P790, DOI 10.1248/cpb.51.790

← 1 2 3 →