Nuclear pore complexes in the maintenance of genome integrity

被引：38
作者：
Bukata, Lucas [1 ]
Parker, Stephanie L. [1 ]
D'Angelo, Maximiliano A. [1 ]
机构：
[1] Univ Calif San Francisco, Cardiovasc Res Inst, Dept Biochem & Biophys, San Francisco, CA 94158 USA
来源：
CURRENT OPINION IN CELL BIOLOGY | 2013年 / 25卷 / 03期
关键词：
STRAND BREAK REPAIR; DNA-DAMAGE RESPONSE; MESSENGER-RNA EXPORT; SPINDLE CHECKPOINT; NUCLEOPORIN NUP153; NUP107-160; COMPLEX; E3; LIGASE; YEAST; SUMO; TELOMERES;
D O I：
10.1016/j.ceb.2013.03.002
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Maintaining genome integrity is crucial for successful organismal propagation and for cell and tissue homeostasis. Several processes contribute to safeguarding the genomic information of cells. These include accurate replication of genetic information, detection and repair of DNA damage, efficient segregation of chromosomes, protection of chromosome ends, and proper organization of genome architecture. Interestingly, recent evidence shows that nuclear pore complexes, the channels connecting the nucleus with the cytoplasm, play important roles in these processes suggesting that these multiprotein platforms are key regulators of genome integrity.
引用
收藏
页码：378 / 386
页数：9
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