Controlled and Sequential Delivery of Fluorophores from 3D Printed Alginate-PLGA Tubes

被引：42
作者：
Do, Anh-Vu [1 ,2 ]
Akkouch, Adil [3 ]
Green, Brian [2 ]
Ozbolat, Ibrahim [3 ,4 ,5 ]
Debabneh, Amer [3 ]
Geary, Sean [1 ]
Salem, Aliasger K. [1 ,2 ]
机构：
[1] Univ Iowa, Coll Pharm, Div Pharmaceut & Translat Therapeut, Iowa City, IA 52242 USA
[2] Univ Iowa, Coll Engn, Dept Chem & Biochem Engn, Iowa City, IA 52242 USA
[3] Univ Iowa, Coll Engn, Ctr Comp Aided Design, Iowa City, IA 52242 USA
[4] Penn State Univ, Dept Engn Sci & Mech, State Coll, PA USA
[5] Penn State Univ, Huck Inst Life Sci, State Coll, PA USA
来源：
ANNALS OF BIOMEDICAL ENGINEERING | 2017年 / 45卷 / 01期
基金：
美国国家科学基金会;
关键词：
Extrusion printing; PLGA; Alginate; Controlled delivery; Differential delivery; Composite materials; BONE REGENERATION; RELEASE PROFILES; MULTIPLE-DRUGS; SYSTEM; TABLETS; TISSUE; MATRICES;
D O I：
10.1007/s10439-016-1648-9
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Controlled drug delivery systems, that include sequential and/or sustained drug delivery, have been utilized to enhance the therapeutic effects of many current drugs by effectively delivering drugs in a time-dependent and repeatable manner. In this study, with the aid of 3D printing technology, a novel drug delivery device was fabricated and tested to evaluate sequential delivery functionality. With an alginate shell and a poly(lactic-co-glycolic acid) (PLGA) core, the fabricated tubes displayed sequential release of distinct fluorescent dyes and showed no cytotoxicity when incubated with the human embryonic kidney (HEK293) cell line or bone marrow stromal stem cells (BMSC). The controlled differential release of drugs or proteins through such a delivery system has the potential to be used in a wide variety of biomedical applications from treating cancer to regenerative medicine.
引用
收藏
页码：297 / 305
页数：9
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