Ultrasound-guided radiofrequency ablation of early breast cancer in a resection specimen: Lessons for further research

被引：7
作者：
Kreb, D. L. [1 ]
Looij, B. G. [2 ]
Ernst, M. F. [1 ]
Rutten, M. J. C. M. [2 ]
Jager, G. J. [2 ]
van der Linden, J. C. [3 ]
Pruijt, J. F. M. [4 ]
Bosscha, K. [1 ]
机构：
[1] Jeroen Bosch Ziekenhuis, Dept Surg, NL-5200 ME Shertogenbosch, Netherlands
[2] Jeroen Bosch Ziekenhuis, Dept Radiol, NL-5200 ME Shertogenbosch, Netherlands
[3] Jeroen Bosch Ziekenhuis, Dept Pathol, NL-5200 ME Shertogenbosch, Netherlands
[4] Jeroen Bosch Ziekenhuis, Dept Oncol, NL-5200 ME Shertogenbosch, Netherlands
来源：
BREAST | 2013年 / 22卷 / 04期
关键词：
Breast cancer; Radiofrequency ablation; Minimally invasive techniques; Cytokeratin; 8; Nicotinamide adenine dinucleotide diaphorase; 20-YEAR FOLLOW-UP; PHASE-II TRIAL; SURGICAL EXCISION; THERMAL ABLATION; CARCINOMA; THERAPY; MASTECTOMY; EXPERIENCE; MRI; US;
D O I：
10.1016/j.breast.2012.11.004
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Purpose: To assess the feasibility and effectiveness of radiofrequency ablation (RFA) in breast cancer, using different histopathologic staining methods to evaluate tissue viability. Materials and methods: In twenty patients with unifocal small (<= 1, 5 cm) invasive ductal carcinoma, ultrasound-guided RFA was performed immediately after surgery. Cell viability was assessed using cytokeratin 8 (CM 8) and nicotinamide adenine dinucleotide diaphorase (NADHD) in addition to hematoxylin eosin (HE). Results: At histopathological examination, ex vivo RFA resulted in complete cell death of the target lesion in 17/20 patients. In two cases viable ductal carcinoma in situ (DCIS) was found just outside the completely ablated lesion. Conclusion: RFA of small invasive breast cancer seems to be a feasible treatment option. Both NADHD and CK 8 demonstrate a clear and comparable demarcation between viable and non-viable tissue. A high level of accuracy is required in proper positioning of the needle electrode and a "hot retraction" is mandatory. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：543 / 547
页数：5
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