Synthesis of Imidazo[1,2-a]pyridines: "Water-Mediated" Hydroamination and Silver-Catalyzed Aminooxygenation

被引:133
作者
Mohan, Darapanem Chandra [1 ]
Rao, Sadu Nageswara [1 ]
Adimurthy, Subbarayappa [1 ]
机构
[1] CSIR, Cent Salt & Marine Chem Res Inst, Bhavnagar 364002, Gujarat, India
关键词
ONE-POT SYNTHESIS; ALKYNES; AMINOPYRIDINES; DERIVATIVES; ZOLPIDEM; ALKENES; ALPIDEM; AMINES;
D O I
10.1021/jo3025303
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Aqueous syntheses of methylimidazo[1,2-a]pyridines without any deliberate addition of catalyst are reported. Imidazo[1,2-a]pyrazine and imidazo[2,1-a]isoquinoline were also obtained in good yields under similar conditions. With acetonitrile as solvent, Ag-catalyzed intra-molecular aminooxygenation produced imidazo[1,2-a]pyridine-3-carbaldehydes in moderate to good yields.
引用
收藏
页码:1266 / 1272
页数:7
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