Synthesis of Imidazo[1,2-a]pyridines: "Water-Mediated" Hydroamination and Silver-Catalyzed Aminooxygenation

被引：133

作者：

Mohan, Darapanem Chandra ^{[1
]}

Rao, Sadu Nageswara ^{[1
]}

Adimurthy, Subbarayappa ^{[1
]}

机构：

[1] CSIR, Cent Salt & Marine Chem Res Inst, Bhavnagar 364002, Gujarat, India

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2013年 / 78卷 / 03期

关键词：

ONE-POT SYNTHESIS; ALKYNES; AMINOPYRIDINES; DERIVATIVES; ZOLPIDEM; ALKENES; ALPIDEM; AMINES;

D O I：

10.1021/jo3025303

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Aqueous syntheses of methylimidazo[1,2-a]pyridines without any deliberate addition of catalyst are reported. Imidazo[1,2-a]pyrazine and imidazo[2,1-a]isoquinoline were also obtained in good yields under similar conditions. With acetonitrile as solvent, Ag-catalyzed intra-molecular aminooxygenation produced imidazo[1,2-a]pyridine-3-carbaldehydes in moderate to good yields.

引用

页码：1266 / 1272

页数：7

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