Targeting colorectal cancer (stem-like) cells using LGR5 directed antibody drug conjugates

被引：9
作者：
Hirsch, Daniela [1 ]
Ried, Thomas [2 ]
机构：
[1] Heidelberg Univ, Univ Med Ctr Mannheim, Inst Pathol, Mannheim, Germany
[2] NCI, Genet Branch, Ctr Canc Res, NIH, Bethesda, MD 20892 USA
来源：
ANNALS OF TRANSLATIONAL MEDICINE | 2016年 / 4卷 / 24期
关键词：
STEM/PROGENITOR CELLS; SMALL-INTESTINE; OVEREXPRESSION; IDENTIFICATION; REGENERATION; RECEPTORS; MARKER; TUMORS; COLON;
D O I：
10.21037/atm.2016.11.78
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
引用
收藏
页数：4
相关论文
共 26 条
[1]   Identification of stem cells in small intestine and colon by marker gene Lgr5 [J].
Barker, Nick ;
van Es, Johan H. ;
Kuipers, Jeroen ;
Kujala, Pekka ;
van den Born, Maaike ;
Cozijnsen, Miranda ;
Haegebarth, Andrea ;
Korving, Jeroen ;
Begthel, Harry ;
Peters, Peter J. ;
Clevers, Hans .
NATURE, 2007, 449 (7165) :1003-U1
[2]   Lgr5+ve Stem/Progenitor Cells Contribute to Nephron Formation during Kidney Development [J].
Barker, Nick ;
Rookmaaker, Maarten B. ;
Kujala, Pekka ;
Ng, Annie ;
Leushacke, Marc ;
Snippert, Hugo ;
van de Wetering, Marc ;
Tan, Shawna ;
Van Es, Johan H. ;
Huch, Meritxell ;
Poulsom, Richard ;
Verhaar, Marianne C. ;
Peters, Peter J. ;
Clevers, Hans .
CELL REPORTS, 2012, 2 (03) :540-552
[3]   Lgr5+ve Stem Cells Drive Self-Renewal in the Stomach and Build Long-Lived Gastric Units In Vitro [J].
Barker, Nick ;
Huch, Meritxell ;
Kujala, Pekka ;
van de Wetering, Marc ;
Snippert, Hugo J. ;
van Es, Johan H. ;
Sato, Toshiro ;
Stange, Daniel E. ;
Begthel, Harry ;
van den Born, Maaike ;
Danenberg, Esther ;
van den Brink, Stieneke ;
Korving, Jeroen ;
Abo, Arie ;
Peters, Peter J. ;
Wright, Nick ;
Poulsom, Richard ;
Clevers, Hans .
CELL STEM CELL, 2010, 6 (01) :25-36
[4]   Crypt stem cells as the cells-of-origin of intestinal cancer [J].
Barker, Nick ;
Ridgway, Rachel A. ;
van Es, Johan H. ;
van de Wetering, Marc ;
Begthel, Harry ;
van den Born, Maaike ;
Danenberg, Esther ;
Clarke, Alan R. ;
Sansom, Owen J. ;
Clevers, Hans .
NATURE, 2009, 457 (7229) :608-U119
[5]   R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/β-catenin signaling [J].
Carmon, Kendra S. ;
Gong, Xing ;
Lin, Qiushi ;
Thomas, Anthony ;
Liu, Qingyun .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (28) :11452-11457
[6]   Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling [J].
de Lau, Wim ;
Barker, Nick ;
Low, Teck Y. ;
Koo, Bon-Kyoung ;
Li, Vivian S. W. ;
Teunissen, Hans ;
Kujala, Pekka ;
Haegebarth, Andrea ;
Peters, Peter J. ;
van de Wetering, Marc ;
Stange, Daniel E. ;
van Es, Johan E. ;
Guardavaccaro, Daniele ;
Schasfoort, Richard B. M. ;
Mohri, Yasuaki ;
Nishimori, Katsuhiko ;
Mohammed, Shabaz ;
Heck, Albert J. R. ;
Clevers, Hans .
NATURE, 2011, 476 (7360) :293-U57
[7]   LGR5-Targeted Antibody-Drug Conjugate Eradicates Gastrointestinal Tumors and Prevents Recurrence [J].
Gong, Xing ;
Azhdarinia, Ali ;
Ghosh, Sukhen C. ;
Xiong, Wei ;
An, Zhiqiang ;
Liu, Qingyun ;
Carmon, Kendra S. .
MOLECULAR CANCER THERAPEUTICS, 2016, 15 (07) :1580-1590
[8]   Transcriptome profiling of LGR5 positive colorectal cancer cells [J].
Hirsch, Daniela ;
Hu, Yue ;
Ried, Thomas ;
Moll, Roland ;
Gaiser, Timo .
GENOMICS DATA, 2014, 2 :212-215
[9]   LGR5 positivity defines stem-like cells in colorectal cancer [J].
Hirsch, Daniela ;
Barker, Nick ;
McNeil, Nicole ;
Hu, Yue ;
Camps, Jordi ;
McKinnon, Katherine ;
Clevers, Hans ;
Ried, Thomas ;
Gaiser, Timo .
CARCINOGENESIS, 2014, 35 (04) :849-858
[10]   In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration [J].
Huch, Meritxell ;
Dorrell, Craig ;
Boj, Sylvia F. ;
van Es, Johan H. ;
Li, Vivian S. W. ;
van de Wetering, Marc ;
Sato, Toshiro ;
Hamer, Karien ;
Sasaki, Nobuo ;
Finegold, Milton J. ;
Haft, Annelise ;
Vries, Robert G. ;
Grompe, Markus ;
Clevers, Hans .
NATURE, 2013, 494 (7436) :247-250
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