Acute left ventricular dysfunction and subarachnoid hemorrhage

Objective: Severe left ventricular (LV) dysfunction associated with acute subarachnoid hemorrhage (SAH) due to cerebral aneurysm rupture. Setting: An adult 12-bed surgical intensive care unit of a university hospital. Patient: A female patient presenting with SAH (Hunt & Hess grade III) and severe left ventricular dysfunction. Interventions: Central venous pressure, arterial blood pressure, extravascular lung water catheter, transesophageal echocardiography, blood gas analysis, electrocardiograms, and chest x-ray for clinical management. Measurements and main results: On admission to the district hospital, an electrocardiogram (ECG) revealed a sinus rhythm with transient ST elevations. A transesophageal echocardiography showed a left ventricular ejection fraction (LV-EF) of approximately 10%, Severe LV dysfunction required inotropic and vasopressor support to maintain mean arterial pressure above 60 mmHg, while the first measurement of an extravascular lung water catheter revealed a cardiac index of 2.0 L/min/m(2) and moderate hypovolemia. Despite stepwise volume loading that increased intrathoracic blood volume-an indicator of cardiac preload-from 719 mL/m(2) to 927 mL/m(2), cardiac index remained poor. Enoximone lead to a marked increase of cardiac index up to 3.9 L/min/m(2) and LV-EF to about 30%, but had to be stopped due to thrombopenia, Surgical clipping of an intracranial aneurysm was postponed because of the impaired cardiac function and was performed on day 18 after admission. Interestingly, neurologic outcome was not as poor as might be expected from the literature. Conclusion: Severe left ventricular dysfunction may occur in acute SAH and may necessitate delay of aneurysm surgery.