Diagnosis of disseminated zygomycosis using a polymerase chain reaction assay

被引:20
作者
Rickerts, V
Loeffler, J
Böhme, A
Einsele, H
Just-Nübling, G
机构
[1] JW Goethe Univ Klinikum, Med Klin Infektiol 3, D-60569 Frankfurt, Germany
[2] Univ Tubingen, Med Klin, Abt 2, D-72076 Tubingen, Germany
关键词
D O I
10.1007/s100960100599
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Invasive pulmonary zygomycosis is an uncommon opportunistic infection in patients with haematological malignancies. Clinical manifestations are indistinguishable from the more frequent invasive aspergillosis. Standard diagnostic methods like culture and microscopy from respiratory secretions have a low diagnostic sensitivity. A case in which proven invasive pulmonary zygomycosis was confirmed using a panfungal polymerase chain reaction assay in blood is presented. Since zygomycosis requires more aggressive treatment than aspergillosis (high-dose amphotericin B and surgical intervention), the polymerase chain reaction assay may improve the outcome of these often fatal infections by guiding the therapeutic approach through an early, noninvasive diagnosis.
引用
收藏
页码:744 / 745
页数:2
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