Elderly at time of COronaVIrus disease 2019 (COVID-19): possible role of immunosenescence and malnutrition

被引：57

作者：

Bencivenga, Leonardo ^{[1
]}

Rengo, Giuseppe ^{[1
,2
]}

Varricchi, Gilda ^{[1
,3
,4
,5
]}

机构：

[1] Univ Naples Federico II, Dept Translat Med Sci, Via Sergio Pansini 5, I-80131 Naples, Italy

[2] ICS Maugeri SpA SB, Ist Clin Sci Maugeri SpA Soc Benefit, Telese Terme, BN, Italy

[3] Univ Naples Federico II, Ctr Basic & Clin Immunol Res CISI, Naples, Italy

[4] WAO Ctr Excellence, Naples, Italy

[5] Natl Res Council CNR, Inst Expt Endocrinol & Oncol G Salvatore IEOS, Naples, Italy

来源：

GEROSCIENCE | 2020年 / 42卷 / 04期

关键词：

Pandemic; COVID-19; Immunosenescence; Malnutrition; Elderly; SUPPLEMENTATION;

D O I：

10.1007/s11357-020-00218-9

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

The unprecedented COVID-19 pandemic is rapidly and unpredictably evolving and the majority of deaths are occurring in older people. A partial description of the magnitude of the scenario is provided by numbers and statistics, which probably underestimate the ongoing tragedy. In the present opinion paper, we have focused our attention on the evidence of the relationship among malnutrition, immunosenescence, and the higher morbidity and mortality in elderly patients. In particular, we propose the intriguing hypothesis that correction of nutritional deficits may attenuate the age-dependent alterations of the innate and adaptive immune system which participate in the increased susceptibility and worse outcome observed in the elderly COVID-19 patients.

引用

收藏

页码：1089 / 1092

页数：4

相关论文

共 21 条

[1] Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention [J].

Aiello, Anna ;

Farzaneh, Farzin ;

Candore, Giuseppina ;

Caruso, Calogero ;

Davinelli, Sergio ;

Gambino, Caterina Maria ;

Ligotti, Mattia Emanuela ;

Zareian, Nahid ;

Accardi, Giulia .

FRONTIERS IN IMMUNOLOGY, 2019, 10

[2]

Alam I., 2019, Nutrition and Healthy Aging, P73, DOI DOI 10.3233/NHA-170034

[3] Effect of zinc supplementation on serum zinc concentration and T cell proliferation in nursing home elderly: a randomized, double-blind, placebo-controlled trial [J].

Barnett, Junaidah B. ;

Dao, Maria C. ;

Hamer, Davidson H. ;

Kandel, Ruth ;

Brandeis, Gary ;

Wu, Dayong ;

Dallal, Gerard E. ;

Jacques, Paul F. ;

Schreiber, Robert ;

Kong, Eunhee ;

Meydani, Simin N. .

AMERICAN JOURNAL OF CLINICAL NUTRITION, 2016, 103 (03) :942-951

[4] Optimal Nutritional Status for a Well-Functioning Immune System Is an Important Factor to Protect against Viral Infections [J].

Calder, Philip C. ;

Carr, Anitra C. ;

Gombart, Adrian F. ;

Eggersdorfer, Manfred .

NUTRIENTS, 2020, 12 (04)

[5] A new clinical trial to test high-dose vitamin C in patients with COVID-19 [J].

Carr, Anitra C. .

CRITICAL CARE, 2020, 24 (01)

[6] Protein intake and exercise for optimal muscle function with aging: Recommendations from the ESPEN Expert Group [J].

Deutz, Nicolaas E. P. ;

Bauer, Juergen M. ;

Barazzoni, Rocco ;

Biolo, Gianni ;

Boirie, Yves ;

Bosy-Westphal, Anja ;

Cederholm, Tommy ;

Cruz-Jentoft, Alfonso ;

Krznaric, Zeljko ;

Nair, K. Sreekumaran ;

Singer, Pierre ;

Teta, Daniel ;

Tipton, Kevin ;

Calder, Philip C. .

CLINICAL NUTRITION, 2014, 33 (06) :929-936

[7] Off-label use of tocilizumab in patients with SARS-CoV-2 infection [J].

Di Giambenedetto, Simona ;

Ciccullo, Arturo ;

Borghetti, Alberto ;

Gambassi, Giovanni ;

Landi, Francesco ;

Visconti, Elena ;

Zileri Dal Verme, Lorenzo ;

Bernabei, Roberto ;

Tamburrini, Enrica ;

Cauda, Roberto ;

Gasbarrini, Antonio .

JOURNAL OF MEDICAL VIROLOGY, 2020, 92 (10) :1787-1788

[8]

Emami A, 2020, ARCH ACAD EMERG MED, V8, DOI 10.22037/aaem.v8i1.600

[9] Impact of Vitamin D Supplementation on Influenza Vaccine Response and Immune Functions in Deficient Elderly Persons: A Randomized Placebo-Controlled Trial [J].

Goncalves-Mendes, Nicolas ;

Talvas, Jeremie ;

Duale, Christian ;

Guttmann, Aline ;

Corbin, Violaine ;

Marceau, Geoffroy ;

Sapin, Vincent ;

Brachet, Patrick ;

Evrard, Bertrand ;

Laurichesse, Henri ;

Vasson, Marie-Paule .

FRONTIERS IN IMMUNOLOGY, 2019, 10

[10] Evidence that Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths [J].

Grant, William B. ;

Lahore, Henry ;

McDonnell, Sharon L. ;

Baggerly, Carole A. ;

French, Christine B. ;

Aliano, Jennifer L. ;

Bhattoa, Harjit P. .

NUTRIENTS, 2020, 12 (04)