Low-hanging fruit: targeting Brdt in the testes

被引：9

作者：

Bryant, Jessica M.

Berger, Shelley L. ^{[1
]}

机构：

[1] Univ Penn, Epigenet Program, Dept Cell & Dev Biol, Philadelphia, PA 19104 USA

来源：

EMBO JOURNAL | 2012年 / 31卷 / 19期

关键词：

BROMODOMAIN; CHROMATIN; INHIBITION;

D O I：

10.1038/emboj.2012.259

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this issue of The EMBO Journal, Gaucher et al (2012) demonstrate that Brdt, a testes-specific member of the BET family of double bromodomain proteins, is intricately involved in the transcriptional regulation and genome reorganization required for the production of viable, fertile sperm. These findings are complimented by a recent publication in Cell (Matzuk et al, 2012) where JQ1, a small molecule BET inhibitor, is effective as a male contraceptive in mice. Both studies establish Brdt as an integral factor in sperm development.

引用

页码：3788 / 3789

页数：2

共 12 条

[1] Selective inhibition of BET bromodomains [J].

Filippakopoulos, Panagis ;

Qi, Jun ;

Picaud, Sarah ;

Shen, Yao ;

Smith, William B. ;

Fedorov, Oleg ;

Morse, Elizabeth M. ;

Keates, Tracey ;

Hickman, Tyler T. ;

Felletar, Ildiko ;

Philpott, Martin ;

Munro, Shonagh ;

McKeown, Michael R. ;

Wang, Yuchuan ;

Christie, Amanda L. ;

West, Nathan ;

Cameron, Michael J. ;

Schwartz, Brian ;

Heightman, Tom D. ;

La Thangue, Nicholas ;

French, Christopher A. ;

Wiest, Olaf ;

Kung, Andrew L. ;

Knapp, Stefan ;

Bradner, James E. .

NATURE, 2010, 468 (7327) :1067-1073

[2] Bromodomain-dependent stage-specific male genome programming by Brdt [J].

Gaucher, Jonathan ;

Boussouar, Faycal ;

Montellier, Emilie ;

Curtet, Sandrine ;

Buchou, Thierry ;

Bertrand, Sarah ;

Hery, Patrick ;

Jounier, Sylvie ;

Depaux, Arnaud ;

Vitte, Anne-Laure ;

Guardiola, Philippe ;

Pernet, Karin ;

Debernardi, Alexandra ;

Lopez, Fabrice ;

Holota, Helene ;

Imbert, Jean ;

Wolgemuth, Debra J. ;

Gerard, Matthieu ;

Rousseaux, Sophie ;

Khochbin, Saadi .

EMBO JOURNAL, 2012, 31 (19) :3809-3820

[3] The role of histones in chromatin remodelling during mammalian spermiogenesis [J].

Govin, J ;

Caron, C ;

Lestrat, C ;

Rousseaux, S ;

Khochbin, S .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 2004, 271 (17) :3459-3469

[4] Genome reprogramming during sporulation [J].

Govin, Jerome ;

Berger, Shelley L. .

INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY, 2009, 53 (2-3) :425-432

[5] Distinctive chromatin in human sperm packages genes for embryo development [J].

Hammoud, Saher Sue ;

Nix, David A. ;

Zhang, Haiying ;

Purwar, Jahnvi ;

Carrell, Douglas T. ;

Cairns, Bradley R. .

NATURE, 2009, 460 (7254) :473-U47

[6] Growth and early postimplantation defects in mice deficient for the bromodomain-containing protein Brd4 [J].

Houzelstein, D ;

Bullock, SL ;

Lynch, DE ;

Grigorieva, EF ;

Wilson, VA ;

Beddington, RSP .

MOLECULAR AND CELLULAR BIOLOGY, 2002, 22 (11) :3794-3802

[7] Small-Molecule Inhibition of BRDT for Male Contraception [J].

Matzuk, Martin M. ;

McKeown, Michael R. ;

Filippakopoulos, Panagis ;

Li, Qinglei ;

Ma, Lang ;

Agno, Julio E. ;

Lemieux, Madeleine E. ;

Picaud, Sarah ;

Yu, Richard N. ;

Qi, Jun ;

Knapp, Stefan ;

Bradner, James E. .

CELL, 2012, 150 (04) :673-684

[8] Cooperative binding of two acetylation marks on a histone tail by a single bromodomain [J].

Moriniere, Jeanne ;

Rousseaux, Sophie ;

Steuerwald, Ulrich ;

Soler-Lopez, Montserrat ;

Curtet, Sandrine ;

Vitte, Anne-Laure ;

Govin, Jerome ;

Gaucher, Jonathan ;

Sadoul, Karin ;

Hart, Darren J. ;

Krijgsveld, Jeroen ;

Khochbin, Saadi ;

Mueller, Christoph W. ;

Petosa, Carlo .

NATURE, 2009, 461 (7264) :664-U112

[9] Bromodomains as therapeutic targets [J].

Muller, Susanne ;

Filippakopoulos, Panagis ;

Knapp, Stefan .

EXPERT REVIEWS IN MOLECULAR MEDICINE, 2011, 13 :1-21

[10] Acetylation-dependent chromatin reorganization by BRDT, a testis-specific bromodomain-containing protein [J].

Pivot-Pajot, C ;

Caron, C ;

Govin, M ;

Vion, A ;

Rousseaux, S ;

Khochbin, S .

MOLECULAR AND CELLULAR BIOLOGY, 2003, 23 (15) :5354-5365

← 1 2 →