Molecular composition and regulation of the Nox family NAD(P)H oxidases

被引：249

作者：

Sumimoto, H

Miyano, K

Takeya, R

机构：

[1] Kyushu Univ, Med Inst Bioregulat, Higashi Ku, Fukuoka 8128582, Japan

[2] CREST, Japan Sci & Technol Agcy, Kawaguchi, Saitama 3320012, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2005年 / 338卷 / 01期

基金：

日本科学技术振兴机构;

关键词：

ROS; Nox; Duox; gp91(phox); p22(phox); p47(phox); p67(phox); Noxo1; Noxa1; Rac;

D O I：

10.1016/j.bbrc.2005.08.210

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Reactive oxygen species (ROS) are conventionally regarded as inevitable deleterious by-products in aerobic metabolism with a few exceptions such as their significant role in host defense. The phagocyte NADPH oxidase, dormant in resting cells, becomes activated during phagocytosis to deliberately produce superoxide, a precursor of other microbicidal ROS, thereby playing a crucial role in killing pathogens. The catalytic center of this oxidase is the membrane-integrated protein gp91(phax), tightly complexed with p22(phox), and its activation requires the association with p47(phox), p67(phox), and the small GTPase Rac, which normally reside in the cytoplasm. Since recent discovery of non-phagocytic gp91(phax)-related enzymes of the NAD(P)H oxidase (Nox) family-seven homologues identified in humans-deliberate ROS production has been increasingly recognized as important components of various cellular events. Here, we describe a current view on the molecular composition and post-translational regulation of Nox-family oxidases in animals. (c) 2005 Elsevier Inc. All rights reserved.

引用

页码：677 / 686

页数：10

共 87 条

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