Using jasplakinolide to turn on pathways that enable the isolation of new chaetoglobosins from Phomospis asparagi

被引：76
作者：
Christian, OE
Compton, J
Christian, KR
Mooberry, SL
Valeriote, FA
Crews, P [1 ]
机构：
[1] Univ Calif Santa Cruz, Dept Chem & Biochem, Santa Cruz, CA 95064 USA
[2] Univ Calif Santa Cruz, Inst Marine Sci, Santa Cruz, CA 95064 USA
[3] SW Fdn Biomed Res, San Antonio, TX 78245 USA
[4] Henry Ford Hlth Syst, Dept Internal Med, Div Hematol & Oncol, Detroit, MI 48202 USA
来源：
JOURNAL OF NATURAL PRODUCTS | 2005年 / 68卷 / 11期
关键词：
D O I：
10.1021/np050293f
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
The isolation and structure elucidation of three new secondary metabolites, chaetoglobosin-510 (1), -540 (2), and -542 (3), are described. These compounds were produced by cultures of the marine-derived fungus Phomopsis asparagi, challenged with the known F-actin inhibitor jasplakinolide. Chaetoglobosin-542 (3) displayed antimicrofilament activity and was cytotoxic toward murine colon and leukemia cancer cell lines.
引用
收藏
页码：1592 / 1597
页数：6
相关论文
共 51 条
  • [31] BIOSYNTHETIC STUDY OF CHAETOGLOBOSIN-A - ORIGINS OF THE OXYGEN AND HYDROGEN-ATOMS, AND INDIRECT EVIDENCE FOR BIOLOGICAL DIELS-ALDER REACTION
    OIKAWA, H
    MURAKAMI, Y
    ICHIHARA, A
    [J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1992, (21): : 2955 - 2959
  • [32] USEFUL APPROACH TO FIND THE PLAUSIBLE BIOSYNTHETIC PRECURSORS OF SECONDARY METABOLITES USING P-450 INHIBITORS - POSTULATED INTERMEDIATES OF CHAETOGLOBOSIN-A1
    OIKAWA, H
    MURAKAMI, Y
    ICHIHARA, A
    [J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1992, (21): : 2949 - 2953
  • [33] Biotransformation of nobiletin by Aspergillus niger and the antimultagenic activity of a metabolite, 4′-hydroxy-5,6,7,8,3′-pentamethoxyflavone
    Okuno, Y
    Miyazawa, M
    [J]. JOURNAL OF NATURAL PRODUCTS, 2004, 67 (11): : 1876 - 1878
  • [34] Biotransformations of the cardiovascular drugs mexrenone and canrenone
    Preisig, CL
    Laakso, JA
    Mocek, UM
    Wang, PT
    Baez, J
    Byng, G
    [J]. JOURNAL OF NATURAL PRODUCTS, 2003, 66 (03): : 350 - 356
  • [35] The structure of microcarpalide, a microfilament disrupting agent from an endophytic fungus
    Ratnayake, AS
    Yoshida, WY
    Mooberry, SL
    Hemscheidt, T
    [J]. ORGANIC LETTERS, 2001, 3 (22) : 3479 - 3481
  • [36] Sanders Miranda, 1999, Memoirs of the Queensland Museum, V44, P525
  • [37] STRUCTURE OF PATULOLIDE-A, A NEW MACROLIDE FROM PENICILLIUM-URTICAE MUTANTS
    SEKIGUCHI, J
    KURODA, H
    YAMADA, Y
    OKADA, H
    [J]. TETRAHEDRON LETTERS, 1985, 26 (19) : 2341 - 2342
  • [38] SEKITA S, 1977, TETRAHEDRON LETT, P2771
  • [39] SEKITA S, 1982, CHEM PHARM BULL, V30, P1629, DOI 10.1248/cpb.30.1629
  • [40] JASPLAKINOLIDES INHIBITION OF THE GROWTH OF PROSTATE CARCINOMA-CELLS IN-VITRO WITH DISRUPTION OF THE ACTIN CYTOSKELETON
    SENDEROWICZ, AMJ
    KAUR, G
    SAINZ, E
    LAING, C
    INMAN, WD
    RODRIGUEZ, J
    CREWS, P
    MALSPEIS, L
    GREVER, MR
    SAUSVILLE, EA
    DUNCAN, KLK
    [J]. JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1995, 87 (01) : 46 - 51
123456