Using jasplakinolide to turn on pathways that enable the isolation of new chaetoglobosins from Phomospis asparagi

被引：76

作者：

Christian, OE

Compton, J

Christian, KR

Mooberry, SL

Valeriote, FA

Crews, P ^{[1
]}

机构：

[1] Univ Calif Santa Cruz, Dept Chem & Biochem, Santa Cruz, CA 95064 USA

[2] Univ Calif Santa Cruz, Inst Marine Sci, Santa Cruz, CA 95064 USA

[3] SW Fdn Biomed Res, San Antonio, TX 78245 USA

[4] Henry Ford Hlth Syst, Dept Internal Med, Div Hematol & Oncol, Detroit, MI 48202 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 2005年 / 68卷 / 11期

关键词：

D O I：

10.1021/np050293f

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The isolation and structure elucidation of three new secondary metabolites, chaetoglobosin-510 (1), -540 (2), and -542 (3), are described. These compounds were produced by cultures of the marine-derived fungus Phomopsis asparagi, challenged with the known F-actin inhibitor jasplakinolide. Chaetoglobosin-542 (3) displayed antimicrofilament activity and was cytotoxic toward murine colon and leukemia cancer cell lines.

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页码：1592 / 1597

页数：6

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