Using jasplakinolide to turn on pathways that enable the isolation of new chaetoglobosins from Phomospis asparagi

被引：76
作者：
Christian, OE
Compton, J
Christian, KR
Mooberry, SL
Valeriote, FA
Crews, P [1 ]
机构：
[1] Univ Calif Santa Cruz, Dept Chem & Biochem, Santa Cruz, CA 95064 USA
[2] Univ Calif Santa Cruz, Inst Marine Sci, Santa Cruz, CA 95064 USA
[3] SW Fdn Biomed Res, San Antonio, TX 78245 USA
[4] Henry Ford Hlth Syst, Dept Internal Med, Div Hematol & Oncol, Detroit, MI 48202 USA
来源：
JOURNAL OF NATURAL PRODUCTS | 2005年 / 68卷 / 11期
关键词：
D O I：
10.1021/np050293f
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
The isolation and structure elucidation of three new secondary metabolites, chaetoglobosin-510 (1), -540 (2), and -542 (3), are described. These compounds were produced by cultures of the marine-derived fungus Phomopsis asparagi, challenged with the known F-actin inhibitor jasplakinolide. Chaetoglobosin-542 (3) displayed antimicrofilament activity and was cytotoxic toward murine colon and leukemia cancer cell lines.
引用
收藏
页码：1592 / 1597
页数：6
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