A case of chromophobe renal cell carcinoma associated with low chromosome number and microsatellite instability

被引：27

作者：

Shuin, T

Kondo, K

Sakai, N

Kaneko, S

Yao, M

Nagashima, Y

Kitamura, H

Yoshida, MA

机构：

[1] YOKOHAMA CITY UNIV,SCH MED,DEPT PATHOL 2,YOKOHAMA,KANAGAWA 236,JAPAN

[2] TOKYO MED & DENT UNIV,MED RES INST,DEPT CYTOGENET,TOKYO,JAPAN

[3] YOKOHAMA CITY UNIV MED,DEPT PATHOL,YOKOHAMA,KANAGAWA,JAPAN

来源：

CANCER GENETICS AND CYTOGENETICS | 1996年 / 86卷 / 01期

关键词：

D O I：

10.1016/0165-4608(95)00167-0

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cytogenetic study in a case of a human chromophobe renal cell carcinoma revealed a hypodiploid chromosome number of 36 with loss of chromosomes 1, 2, 5, 6, 10, 13, 15, 17, 21, and X. The tumor DNA showed microsatellite instability in dinucleotide repeat microsatellite markers. This is the fourth case that has been fully karyotyped and showed a low chromosome number in a chromophobe renal cell carcinoma. Our data in the present study are consistent with those in the literature. It is suggested that human chromophobe renal cell carcinoma may possibly be characterized by tumor cells with low chromosome number or microsatellite instability.

引用

页码：69 / 71

页数：3

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