Enhanced cellular uptake of amphiphilic gold nanoparticles with ester functionality

被引：12

作者：

Kobayashi, Kenya ^{[1
]}

Niikura, Kenichi ^{[2
]}

Takeuchi, Chie ^{[2
]}

Sekiguchi, Shota ^{[3
]}

Ninomiya, Takafumi ^{[4
]}

Hagiwara, Kyoji ^{[1
]}

Mitomo, Hideyuki ^{[2
]}

Ito, Yoshihiro ^{[1
]}

Osada, Yoshihito ^{[1
]}

Ijiro, Kuniharu ^{[2
]}

机构：

[1] RIKEN, Nano Med Engn Lab, Wako, Saitama 3510198, Japan

[2] Hokkaido Univ, Res Inst Elect Sci, Kita Ku, Sapporo, Hokkaido 0010021, Japan

[3] Hokkaido Univ, Grad Sch Chem Sci & Engn, Kita Ku, Sapporo, Hokkaido 0010021, Japan

[4] Sapporo Med Univ, Sch Med, Dept Anat 1, Chuo Ku, Sapporo, Hokkaido 0608556, Japan

来源：

CHEMICAL COMMUNICATIONS | 2014年 / 50卷 / 10期

关键词：

DELIVERY; PENETRATION; SPIROPYRAN; MEMBRANE; CARRIERS;

D O I：

10.1039/c3cc48532c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Gold nanoparticles (AuNPs) coated with ester-headed or ether-headed PEG ligands were synthesized. Ester-headed AuNPs, but not ether-headed, were transferred from the organic phase (CH2Cl2) to the alkali aqueous phase, indicating that the hydrolysis of the ester moiety triggered the phase transfer of the AuNPs. We found that AuNPs with ester-headed ligands (ester-AuNPs) were internalized into HeLa cells at a greater level than were ether-headed AuNPs.

引用

页码：1265 / 1267

页数：3

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