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Amyloid-β may be released from non-junctional varicosities of axons generated from abnormal tau-containing brainstem nuclei in sporadic Alzheimer's disease: a hypothesis
被引:29
作者
:
Braak, Heiko
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Ulm, Clin Neuroanat Sect, Dept Neurol, Ctr Biomed Res, D-89081 Ulm, Germany
Univ Ulm, Clin Neuroanat Sect, Dept Neurol, Ctr Biomed Res, D-89081 Ulm, Germany
Braak, Heiko
[
1
]
Del Tredici, Kelly
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Ulm, Clin Neuroanat Sect, Dept Neurol, Ctr Biomed Res, D-89081 Ulm, Germany
Univ Ulm, Clin Neuroanat Sect, Dept Neurol, Ctr Biomed Res, D-89081 Ulm, Germany
Del Tredici, Kelly
[
1
]
机构
:
[1]
Univ Ulm, Clin Neuroanat Sect, Dept Neurol, Ctr Biomed Res, D-89081 Ulm, Germany
来源
:
ACTA NEUROPATHOLOGICA
|
2013年
/ 126卷
/ 02期
关键词
:
MILD COGNITIVE IMPAIRMENT;
NEUROFIBRILLARY DEGENERATION;
NEUROPATHOLOGIC ASSESSMENT;
ASSOCIATION GUIDELINES;
NATIONAL INSTITUTE;
DEPOSITION;
PLAQUES;
PROTEIN;
EVOLUTION;
PATHOLOGY;
D O I
:
10.1007/s00401-013-1153-2
中图分类号
:
R74 [神经病学与精神病学];
学科分类号
:
摘要
:
引用
收藏
页码:303 / 306
页数:4
相关论文
共 51 条
[1]
VOLUME VERSUS WIRING TRANSMISSION IN THE BRAIN - A NEW THEORETICAL FRAME FOR NEUROPSYCHOPHARMACOLOGY
[J].
AGNATI, LF
论文数:
0
引用数:
0
h-index:
0
机构:
KAROLINSKA INST,DEPT NEUROSCI,STOCKHOLM,SWEDEN
KAROLINSKA INST,DEPT NEUROSCI,STOCKHOLM,SWEDEN
AGNATI, LF
;
BJELKE, B
论文数:
0
引用数:
0
h-index:
0
机构:
KAROLINSKA INST,DEPT NEUROSCI,STOCKHOLM,SWEDEN
KAROLINSKA INST,DEPT NEUROSCI,STOCKHOLM,SWEDEN
BJELKE, B
;
FUXE, K
论文数:
0
引用数:
0
h-index:
0
机构:
KAROLINSKA INST,DEPT NEUROSCI,STOCKHOLM,SWEDEN
KAROLINSKA INST,DEPT NEUROSCI,STOCKHOLM,SWEDEN
FUXE, K
.
MEDICINAL RESEARCH REVIEWS,
1995,
15
(01)
:33
-45
[2]
Striatal Amyloid Plaque Density Predicts Braak Neurofibrillary Stage and Clinicopathological Alzheimer's Disease: Implications for Amyloid Imaging
[J].
Beach, Thomas G.
论文数:
0
引用数:
0
h-index:
0
机构:
Banner Sun Hlth Res Inst, Sun City, AZ 85351 USA
Banner Sun Hlth Res Inst, Sun City, AZ 85351 USA
Beach, Thomas G.
;
Sue, Lucia I.
论文数:
0
引用数:
0
h-index:
0
机构:
Banner Sun Hlth Res Inst, Sun City, AZ 85351 USA
Banner Sun Hlth Res Inst, Sun City, AZ 85351 USA
Sue, Lucia I.
;
Walker, Douglas G.
论文数:
0
引用数:
0
h-index:
0
机构:
Banner Sun Hlth Res Inst, Sun City, AZ 85351 USA
Banner Sun Hlth Res Inst, Sun City, AZ 85351 USA
Walker, Douglas G.
;
Sabbagh, Marwan N.
论文数:
0
引用数:
0
h-index:
0
机构:
Banner Sun Hlth Res Inst, Sun City, AZ 85351 USA
Banner Sun Hlth Res Inst, Sun City, AZ 85351 USA
Sabbagh, Marwan N.
;
Serrano, Geidy
论文数:
0
引用数:
0
h-index:
0
机构:
Banner Sun Hlth Res Inst, Sun City, AZ 85351 USA
Banner Sun Hlth Res Inst, Sun City, AZ 85351 USA
Serrano, Geidy
;
Dugger, Brittany N.
论文数:
0
引用数:
0
h-index:
0
机构:
Banner Sun Hlth Res Inst, Sun City, AZ 85351 USA
Banner Sun Hlth Res Inst, Sun City, AZ 85351 USA
Dugger, Brittany N.
;
Mariner, Monica
论文数:
0
引用数:
0
h-index:
0
机构:
Banner Sun Hlth Res Inst, Sun City, AZ 85351 USA
Banner Sun Hlth Res Inst, Sun City, AZ 85351 USA
Mariner, Monica
;
Yantos, Kim
论文数:
0
引用数:
0
h-index:
0
机构:
Banner Sun Hlth Res Inst, Sun City, AZ 85351 USA
Banner Sun Hlth Res Inst, Sun City, AZ 85351 USA
Yantos, Kim
;
Henry-Watson, Jonette
论文数:
0
引用数:
0
h-index:
0
机构:
Banner Sun Hlth Res Inst, Sun City, AZ 85351 USA
Banner Sun Hlth Res Inst, Sun City, AZ 85351 USA
Henry-Watson, Jonette
;
Chiarolanza, Glenn
论文数:
0
引用数:
0
h-index:
0
机构:
Banner Sun Hlth Res Inst, Sun City, AZ 85351 USA
Banner Sun Hlth Res Inst, Sun City, AZ 85351 USA
Chiarolanza, Glenn
;
Hidalgo, Jose A.
论文数:
0
引用数:
0
h-index:
0
机构:
Banner Sun Hlth Res Inst, Sun City, AZ 85351 USA
Banner Sun Hlth Res Inst, Sun City, AZ 85351 USA
Hidalgo, Jose A.
;
Souders, Leslie
论文数:
0
引用数:
0
h-index:
0
机构:
Banner Sun Hlth Res Inst, Sun City, AZ 85351 USA
Banner Sun Hlth Res Inst, Sun City, AZ 85351 USA
Souders, Leslie
.
JOURNAL OF ALZHEIMERS DISEASE,
2012,
28
(04)
:869
-876
[3]
Blennow K, 2012, COLD SPRING HARB PER, V2
[4]
Alzheimer's disease:: intraneuronal alterations precede insoluble amyloid-β formation
[J].
Braak, H
论文数:
0
引用数:
0
h-index:
0
机构:
Goethe Univ Frankfurt, Inst Clin Neuroanat, D-60590 Frankfurt, Germany
Goethe Univ Frankfurt, Inst Clin Neuroanat, D-60590 Frankfurt, Germany
Braak, H
;
Del Tredici, K
论文数:
0
引用数:
0
h-index:
0
机构:
Goethe Univ Frankfurt, Inst Clin Neuroanat, D-60590 Frankfurt, Germany
Goethe Univ Frankfurt, Inst Clin Neuroanat, D-60590 Frankfurt, Germany
Del Tredici, K
.
NEUROBIOLOGY OF AGING,
2004,
25
(06)
:713
-718
[5]
ALZHEIMERS-DISEASE - STRIATAL AMYLOID DEPOSITS AND NEUROFIBRILLARY CHANGES
[J].
BRAAK, H
论文数:
0
引用数:
0
h-index:
0
机构:
Department of Morphology, J. W. Goethe-University, Frankfurt/Main
BRAAK, H
;
BRAAK, E
论文数:
0
引用数:
0
h-index:
0
机构:
Department of Morphology, J. W. Goethe-University, Frankfurt/Main
BRAAK, E
.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY,
1990,
49
(03)
:215
-224
[6]
ALZHEIMERS-DISEASE - AMYLOID PLAQUES IN THE CEREBELLUM
[J].
BRAAK, H
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV MAINZ,DEPT NEUROPATHOL,D-6500 MAINZ,FED REP GER
BRAAK, H
;
BRAAK, E
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV MAINZ,DEPT NEUROPATHOL,D-6500 MAINZ,FED REP GER
BRAAK, E
;
BOHL, J
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV MAINZ,DEPT NEUROPATHOL,D-6500 MAINZ,FED REP GER
BOHL, J
;
LANG, W
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV MAINZ,DEPT NEUROPATHOL,D-6500 MAINZ,FED REP GER
LANG, W
.
JOURNAL OF THE NEUROLOGICAL SCIENCES,
1989,
93
(2-3)
:277
-287
[7]
NEUROPATHOLOGICAL STAGING OF ALZHEIMER-RELATED CHANGES
[J].
BRAAK, H
论文数:
0
引用数:
0
h-index:
0
机构:
ZENTRUM MORPHOL, THEODOR STERN KAI 7, W-6000 FRANKFURT 70, GERMANY
ZENTRUM MORPHOL, THEODOR STERN KAI 7, W-6000 FRANKFURT 70, GERMANY
BRAAK, H
;
BRAAK, E
论文数:
0
引用数:
0
h-index:
0
机构:
ZENTRUM MORPHOL, THEODOR STERN KAI 7, W-6000 FRANKFURT 70, GERMANY
ZENTRUM MORPHOL, THEODOR STERN KAI 7, W-6000 FRANKFURT 70, GERMANY
BRAAK, E
.
ACTA NEUROPATHOLOGICA,
1991,
82
(04)
:239
-259
[8]
Intraneuronal tau aggregation precedes diffuse plaque deposition, but amyloid-β changes occur before increases of tau in cerebrospinal fluid
[J].
Braak, Heiko
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Ulm, Clin Neuroanat Sect, Dept Neurol, Ctr Biomed Res, D-89081 Ulm, Germany
Univ Ulm, Clin Neuroanat Sect, Dept Neurol, Ctr Biomed Res, D-89081 Ulm, Germany
Braak, Heiko
;
Zetterberg, Henrik
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Gothenburg, Clin Neurochem Lab, Inst Neurosci & Physiol, Sahlgrenska Univ Hosp,Sahlgrenska Acad, S-43180 Molndal, Sweden
UCL Inst Neurol, London WC1N 3BG, England
Univ Ulm, Clin Neuroanat Sect, Dept Neurol, Ctr Biomed Res, D-89081 Ulm, Germany
Zetterberg, Henrik
;
Del Tredici, Kelly
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Ulm, Clin Neuroanat Sect, Dept Neurol, Ctr Biomed Res, D-89081 Ulm, Germany
Univ Ulm, Clin Neuroanat Sect, Dept Neurol, Ctr Biomed Res, D-89081 Ulm, Germany
Del Tredici, Kelly
;
Blennow, Kaj
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Gothenburg, Clin Neurochem Lab, Inst Neurosci & Physiol, Sahlgrenska Univ Hosp,Sahlgrenska Acad, S-43180 Molndal, Sweden
Univ Ulm, Clin Neuroanat Sect, Dept Neurol, Ctr Biomed Res, D-89081 Ulm, Germany
Blennow, Kaj
.
ACTA NEUROPATHOLOGICA,
2013,
126
(05)
:631
-641
[9]
Where, when, and in what form does sporadic Alzheimer's disease begin?
[J].
Braak, Heiko
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Ulm, Clin Neuroanat Sect, Dept Neurol, Ctr Biomed Res, D-89081 Ulm, Germany
Univ Ulm, Clin Neuroanat Sect, Dept Neurol, Ctr Biomed Res, D-89081 Ulm, Germany
Braak, Heiko
;
Del Tredici, Kelly
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Ulm, Clin Neuroanat Sect, Dept Neurol, Ctr Biomed Res, D-89081 Ulm, Germany
Univ Ulm, Clin Neuroanat Sect, Dept Neurol, Ctr Biomed Res, D-89081 Ulm, Germany
Del Tredici, Kelly
.
CURRENT OPINION IN NEUROLOGY,
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25
(06)
:708
-714
[10]
Stages of the Pathologic Process in Alzheimer Disease: Age Categories From 1 to 100 Years
[J].
Braak, Heiko
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Ulm, Clin Res Ctr, Dept Neurol, D-89081 Ulm, Germany
Univ Ulm, Clin Res Ctr, Dept Neurol, D-89081 Ulm, Germany
Braak, Heiko
;
Thal, Dietmar R.
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Ulm, Clin Res Ctr, Neuropathol Lab, Inst Pathol, D-89081 Ulm, Germany
Univ Ulm, Clin Res Ctr, Dept Neurol, D-89081 Ulm, Germany
Thal, Dietmar R.
;
Ghebremedhin, Estifanos
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Ulm, Clin Res Ctr, Neuropathol Lab, Inst Pathol, D-89081 Ulm, Germany
Univ Queensland, Sch Biomed Sci, Dept Anat & Dev Biol, Brisbane, Qld, Australia
Univ Ulm, Clin Res Ctr, Dept Neurol, D-89081 Ulm, Germany
Ghebremedhin, Estifanos
;
Del Tredici, Kelly
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Ulm, Clin Res Ctr, Dept Neurol, D-89081 Ulm, Germany
Univ Ulm, Clin Res Ctr, Dept Neurol, D-89081 Ulm, Germany
Del Tredici, Kelly
.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY,
2011,
70
(11)
:960
-969
←
1
2
3
4
5
6
→
共 51 条
[1]
VOLUME VERSUS WIRING TRANSMISSION IN THE BRAIN - A NEW THEORETICAL FRAME FOR NEUROPSYCHOPHARMACOLOGY
[J].
AGNATI, LF
论文数:
0
引用数:
0
h-index:
0
机构:
KAROLINSKA INST,DEPT NEUROSCI,STOCKHOLM,SWEDEN
KAROLINSKA INST,DEPT NEUROSCI,STOCKHOLM,SWEDEN
AGNATI, LF
;
BJELKE, B
论文数:
0
引用数:
0
h-index:
0
机构:
KAROLINSKA INST,DEPT NEUROSCI,STOCKHOLM,SWEDEN
KAROLINSKA INST,DEPT NEUROSCI,STOCKHOLM,SWEDEN
BJELKE, B
;
FUXE, K
论文数:
0
引用数:
0
h-index:
0
机构:
KAROLINSKA INST,DEPT NEUROSCI,STOCKHOLM,SWEDEN
KAROLINSKA INST,DEPT NEUROSCI,STOCKHOLM,SWEDEN
FUXE, K
.
MEDICINAL RESEARCH REVIEWS,
1995,
15
(01)
:33
-45
[2]
Striatal Amyloid Plaque Density Predicts Braak Neurofibrillary Stage and Clinicopathological Alzheimer's Disease: Implications for Amyloid Imaging
[J].
Beach, Thomas G.
论文数:
0
引用数:
0
h-index:
0
机构:
Banner Sun Hlth Res Inst, Sun City, AZ 85351 USA
Banner Sun Hlth Res Inst, Sun City, AZ 85351 USA
Beach, Thomas G.
;
Sue, Lucia I.
论文数:
0
引用数:
0
h-index:
0
机构:
Banner Sun Hlth Res Inst, Sun City, AZ 85351 USA
Banner Sun Hlth Res Inst, Sun City, AZ 85351 USA
Sue, Lucia I.
;
Walker, Douglas G.
论文数:
0
引用数:
0
h-index:
0
机构:
Banner Sun Hlth Res Inst, Sun City, AZ 85351 USA
Banner Sun Hlth Res Inst, Sun City, AZ 85351 USA
Walker, Douglas G.
;
Sabbagh, Marwan N.
论文数:
0
引用数:
0
h-index:
0
机构:
Banner Sun Hlth Res Inst, Sun City, AZ 85351 USA
Banner Sun Hlth Res Inst, Sun City, AZ 85351 USA
Sabbagh, Marwan N.
;
Serrano, Geidy
论文数:
0
引用数:
0
h-index:
0
机构:
Banner Sun Hlth Res Inst, Sun City, AZ 85351 USA
Banner Sun Hlth Res Inst, Sun City, AZ 85351 USA
Serrano, Geidy
;
Dugger, Brittany N.
论文数:
0
引用数:
0
h-index:
0
机构:
Banner Sun Hlth Res Inst, Sun City, AZ 85351 USA
Banner Sun Hlth Res Inst, Sun City, AZ 85351 USA
Dugger, Brittany N.
;
Mariner, Monica
论文数:
0
引用数:
0
h-index:
0
机构:
Banner Sun Hlth Res Inst, Sun City, AZ 85351 USA
Banner Sun Hlth Res Inst, Sun City, AZ 85351 USA
Mariner, Monica
;
Yantos, Kim
论文数:
0
引用数:
0
h-index:
0
机构:
Banner Sun Hlth Res Inst, Sun City, AZ 85351 USA
Banner Sun Hlth Res Inst, Sun City, AZ 85351 USA
Yantos, Kim
;
Henry-Watson, Jonette
论文数:
0
引用数:
0
h-index:
0
机构:
Banner Sun Hlth Res Inst, Sun City, AZ 85351 USA
Banner Sun Hlth Res Inst, Sun City, AZ 85351 USA
Henry-Watson, Jonette
;
Chiarolanza, Glenn
论文数:
0
引用数:
0
h-index:
0
机构:
Banner Sun Hlth Res Inst, Sun City, AZ 85351 USA
Banner Sun Hlth Res Inst, Sun City, AZ 85351 USA
Chiarolanza, Glenn
;
Hidalgo, Jose A.
论文数:
0
引用数:
0
h-index:
0
机构:
Banner Sun Hlth Res Inst, Sun City, AZ 85351 USA
Banner Sun Hlth Res Inst, Sun City, AZ 85351 USA
Hidalgo, Jose A.
;
Souders, Leslie
论文数:
0
引用数:
0
h-index:
0
机构:
Banner Sun Hlth Res Inst, Sun City, AZ 85351 USA
Banner Sun Hlth Res Inst, Sun City, AZ 85351 USA
Souders, Leslie
.
JOURNAL OF ALZHEIMERS DISEASE,
2012,
28
(04)
:869
-876
[3]
Blennow K, 2012, COLD SPRING HARB PER, V2
[4]
Alzheimer's disease:: intraneuronal alterations precede insoluble amyloid-β formation
[J].
Braak, H
论文数:
0
引用数:
0
h-index:
0
机构:
Goethe Univ Frankfurt, Inst Clin Neuroanat, D-60590 Frankfurt, Germany
Goethe Univ Frankfurt, Inst Clin Neuroanat, D-60590 Frankfurt, Germany
Braak, H
;
Del Tredici, K
论文数:
0
引用数:
0
h-index:
0
机构:
Goethe Univ Frankfurt, Inst Clin Neuroanat, D-60590 Frankfurt, Germany
Goethe Univ Frankfurt, Inst Clin Neuroanat, D-60590 Frankfurt, Germany
Del Tredici, K
.
NEUROBIOLOGY OF AGING,
2004,
25
(06)
:713
-718
[5]
ALZHEIMERS-DISEASE - STRIATAL AMYLOID DEPOSITS AND NEUROFIBRILLARY CHANGES
[J].
BRAAK, H
论文数:
0
引用数:
0
h-index:
0
机构:
Department of Morphology, J. W. Goethe-University, Frankfurt/Main
BRAAK, H
;
BRAAK, E
论文数:
0
引用数:
0
h-index:
0
机构:
Department of Morphology, J. W. Goethe-University, Frankfurt/Main
BRAAK, E
.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY,
1990,
49
(03)
:215
-224
[6]
ALZHEIMERS-DISEASE - AMYLOID PLAQUES IN THE CEREBELLUM
[J].
BRAAK, H
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV MAINZ,DEPT NEUROPATHOL,D-6500 MAINZ,FED REP GER
BRAAK, H
;
BRAAK, E
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV MAINZ,DEPT NEUROPATHOL,D-6500 MAINZ,FED REP GER
BRAAK, E
;
BOHL, J
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV MAINZ,DEPT NEUROPATHOL,D-6500 MAINZ,FED REP GER
BOHL, J
;
LANG, W
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV MAINZ,DEPT NEUROPATHOL,D-6500 MAINZ,FED REP GER
LANG, W
.
JOURNAL OF THE NEUROLOGICAL SCIENCES,
1989,
93
(2-3)
:277
-287
[7]
NEUROPATHOLOGICAL STAGING OF ALZHEIMER-RELATED CHANGES
[J].
BRAAK, H
论文数:
0
引用数:
0
h-index:
0
机构:
ZENTRUM MORPHOL, THEODOR STERN KAI 7, W-6000 FRANKFURT 70, GERMANY
ZENTRUM MORPHOL, THEODOR STERN KAI 7, W-6000 FRANKFURT 70, GERMANY
BRAAK, H
;
BRAAK, E
论文数:
0
引用数:
0
h-index:
0
机构:
ZENTRUM MORPHOL, THEODOR STERN KAI 7, W-6000 FRANKFURT 70, GERMANY
ZENTRUM MORPHOL, THEODOR STERN KAI 7, W-6000 FRANKFURT 70, GERMANY
BRAAK, E
.
ACTA NEUROPATHOLOGICA,
1991,
82
(04)
:239
-259
[8]
Intraneuronal tau aggregation precedes diffuse plaque deposition, but amyloid-β changes occur before increases of tau in cerebrospinal fluid
[J].
Braak, Heiko
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Ulm, Clin Neuroanat Sect, Dept Neurol, Ctr Biomed Res, D-89081 Ulm, Germany
Univ Ulm, Clin Neuroanat Sect, Dept Neurol, Ctr Biomed Res, D-89081 Ulm, Germany
Braak, Heiko
;
Zetterberg, Henrik
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Gothenburg, Clin Neurochem Lab, Inst Neurosci & Physiol, Sahlgrenska Univ Hosp,Sahlgrenska Acad, S-43180 Molndal, Sweden
UCL Inst Neurol, London WC1N 3BG, England
Univ Ulm, Clin Neuroanat Sect, Dept Neurol, Ctr Biomed Res, D-89081 Ulm, Germany
Zetterberg, Henrik
;
Del Tredici, Kelly
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Ulm, Clin Neuroanat Sect, Dept Neurol, Ctr Biomed Res, D-89081 Ulm, Germany
Univ Ulm, Clin Neuroanat Sect, Dept Neurol, Ctr Biomed Res, D-89081 Ulm, Germany
Del Tredici, Kelly
;
Blennow, Kaj
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Gothenburg, Clin Neurochem Lab, Inst Neurosci & Physiol, Sahlgrenska Univ Hosp,Sahlgrenska Acad, S-43180 Molndal, Sweden
Univ Ulm, Clin Neuroanat Sect, Dept Neurol, Ctr Biomed Res, D-89081 Ulm, Germany
Blennow, Kaj
.
ACTA NEUROPATHOLOGICA,
2013,
126
(05)
:631
-641
[9]
Where, when, and in what form does sporadic Alzheimer's disease begin?
[J].
Braak, Heiko
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