Neuroregenerative strategies in the brain: emerging significance of bone morphogenetic protein 7 (BMP7)

被引：0
作者：
Bani-Yaghoub, Mahmud [1 ,2 ]
Tremblay, Roger G. [1 ]
Ajji, Abdellah [3 ]
Nzau, Munyao [4 ,5 ]
Gangaraju, Sandhya [1 ]
Chitty, David [1 ]
Zurakowski, Bogdan [1 ]
Sikorska, Marianna [1 ,2 ]
机构：
[1] Natl Res Council Canada, Inst Biol Sci, Neurobiol Program, Neurogenesis & Brain Repair Grp, Ottawa, ON K1A 0R6, Canada
[2] Univ Ottawa, Fac Med, Ottawa, ON K1H 8M5, Canada
[3] Natl Res Council Canada, Inst Ind Mat, Funct Polymer Syst Grp, Boucherville, PQ J4B 6Y4, Canada
[4] Univ Ottawa, Fac Med, Ottawa, ON K1H 8M5, Canada
[5] Childrens Hosp Eastern Ontario, Div Neurosurg, Ottawa, ON K1H 8L1, Canada
来源：
BIOCHEMISTRY AND CELL BIOLOGY | 2008年 / 86卷 / 05期
关键词：
cell implantation; motor cortex; neurogenesis; neuroregeneration; neurosurgery; polyglycolic acid (PGA); polymer scaffolds;
D O I：
10.1139/O08-116
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Every year thousands of people suffer from brain injuries and stroke, and develop motor, sensory, and cognitive problems as a result of neuronal loss in the brain. Unfortunately, the damaged brain has a limited ability to enact repair and current modes of treatment are not sufficient to offset the damage. An extensive list of growth factors, neurotrophic factors, cytokines, and drugs has been explored as potential therapies. However, only a limited number of them may actually have the potential to effectively offset the brain injury or stroke-related problems. One of the treatments considered for future brain repair is bone morphogenetic protein 7 (BMP7), a factor currently used in patients to treat non-neurological diseases. The clinical application of BMP7 is based on its neuroprotective role in stroke animal models. This paper reviews the current approaches considered for brain repair and discusses the novel convergent strategies by which BMP7 potentially can induce neuroregeneration.
引用
收藏
页码：361 / 369
页数：9
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