What is the future of (ultra) high performance liquid chromatography coupled to low and high resolution mass spectrometry for toxicological drug screening?

被引：77

作者：

Maurer, Hans H. ^{[1
]}

机构：

[1] Univ Saarland, Inst Expt & Clin Pharmacol & Toxicol, Dept Expt & Clin Toxicol, D-66421 Homburg, Saar, Germany

来源：

JOURNAL OF CHROMATOGRAPHY A | 2013年 / 1292卷

关键词：

LC-MS; UHPLC; HRMS; Drug screening; Clinical toxicology; Forensic toxicology; INTER-LABORATORY TRANSFERABILITY; HUMAN LIVER-MICROSOMES; PRODUCT ION SPECTRA; LC-MS/MS METHOD; ELECTROSPRAY-IONIZATION; EXHALED BREATH; REFERENCE LIBRARY; CHEMICAL-IONIZATION; RELEVANT COMPOUNDS; TOXIC COMPOUNDS;

D O I：

10.1016/j.chroma.2012.08.069

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

This paper reviews critically LC-MS approaches for toxicological drug screening using (ultra) high performance liquid chromatography (UHPLC) coupled to low and high resolution mass spectrometry (HRMS) published since 2010. A concluding discussion focuses on progress and current status of sample workup, separation by HPLC vs. UHPLC, MS detection modes and their specificity, universality of LC-MS libraries, and validation necessary of LC-MS for screening methods. Finally, a discussion on what the future holds for LC-MS drug screening in clinical and forensic toxicology completes this review article. (c) 2012 Elsevier B.V. All rights reserved.

引用

页码：19 / 24

页数：6

共 95 条

[1] Interference by venlafaxine ingestion in the detection of tramadol by liquid chromatography linked to tandem mass spectrometry for the screening of illicit drugs in human urine [J].

Allen, KR .

CLINICAL TOXICOLOGY, 2006, 44 (02) :147-153

[2] Direct injection LC-MS/MS method for identification and quantification of amphetamine, methamphetamine, 3,4-methylenedioxyamphetamine and 3,4-methylenedioxymethamphetamine in urine drug testing [J].

Andersson, M. ;

Gustavsson, E. ;

Stephanson, N. ;

Beck, O. .

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2008, 861 (01) :22-28

[3]

[Anonymous], WILEY REGISTRY MASS

[4]

[Anonymous], 2011, MASS SPECTRAL GC DAT

[5] Detection of Δ9-Tetrahydrocannabinol in Exhaled Breath Collected from Cannabis Users [J].

Beck, Olof ;

Sandqvist, Soren ;

Dubbelboer, Ilse ;

Franck, Johan .

JOURNAL OF ANALYTICAL TOXICOLOGY, 2011, 35 (08) :541-544

[6] Study on the Sampling of Methadone from Exhaled Breath [J].

Beck, Olof ;

Sandqvist, Soren ;

Boettcher, Michael ;

Eriksen, Paul ;

Franck, Johan ;

Palmskog, Goran .

JOURNAL OF ANALYTICAL TOXICOLOGY, 2011, 35 (05) :257-263

[7] Determination of Methadone in Exhaled Breath Condensate by Liquid Chromatography-Tandem Mass Spectrometry [J].

Beck, Olof ;

Sandqvist, Soren ;

Eriksen, Paul ;

Franck, Johan ;

Palmskog, Goran .

JOURNAL OF ANALYTICAL TOXICOLOGY, 2011, 35 (03) :129-133

[8] Method for determination of methadone in exhaled breath collected from subjects undergoing methadone maintenance treatment [J].

Beck, Olof ;

Sandqvist, Soeren ;

Eriksen, Paul ;

Franck, Johan ;

Palmskog, Goeran .

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2010, 878 (24) :2255-2259

[9] Amphetamines Detected in Exhaled Breath from Drug Addicts: A New Possible Method for Drugs-of-Abuse Testing [J].

Beck, Olof ;

Leine, Kathinka ;

Palmskog, Goran ;

Franck, Johan .

JOURNAL OF ANALYTICAL TOXICOLOGY, 2010, 34 (05) :233-237

[10] Development of a rapid LC-MS/MS method for direct urinalysis of designer drugs [J].

Bell, Charlotte ;

George, Claire ;

Kicman, Andrew T. ;

Traynor, Allan .

DRUG TESTING AND ANALYSIS, 2011, 3 (7-8) :496-504

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