Ruthenium-Catalyzed Remote Electronic Activation of Aromatic CF Bonds

被引：12

作者：

Watson, Andrew J. A. ^{[1
]}

Atkinson, Benjamin N. ^{[1
]}

Maxwell, Aoife C. ^{[2
]}

Williams, Jonathan M. J. ^{[1
]}

机构：

[1] Univ Bath, Dept Chem, Bath BA2 7AY, Avon, England

[2] GlaxoSmithKline Res & Dev Ltd, Stevenage SG1 2NY, Herts, England

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2013年 / 355卷 / 04期

基金：

英国工程与自然科学研究理事会;

关键词：

arenes; isomerization; nucleophilic substitution; ruthenium; TRANSFER HYDROGENATION; ALLYLIC ALCOHOLS; BORROWING HYDROGEN; OXIDATION; ISOMERIZATION; AMINES;

D O I：

10.1002/adsc.201200879

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The tandem isomerization and nucleophilic aromatic substitution of allylic fluoro-substituted benzylic alcohols is described for the first time. In the presence of the ruthenium complex Ru(PPh3)3(CO)(H)2, 1-(4-fluorophenyl)prop-2-en-1-ol is converted into the corresponding para-amino ketone or para-phenolic substituted ketone.

引用

页码：734 / 740

页数：7

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