BK virus infection in allogeneic hematopoietic cell transplantation: An update on pathogenesis, immune responses, diagnosis and treatments

被引：21

作者：

Saade, Anastasia ^{[1
]}

Styczynski, Jan ^{[2
]}

Cesaro, Simone ^{[3
]}

机构：

[1] Ctr Hosp Univ Rennes, Dept Hematol, Ponchaillou, France

[2] Nicolaus Copernicus Univ Torun, Coll Med, Dept Pediat Hematol & Oncol, Bydgoszcz, Poland

[3] Azienda Osped Univ Integrata Verona, Pediat Hematol Oncol, Verona, Italy

来源：

JOURNAL OF INFECTION | 2020年 / 81卷 / 03期

关键词：

BK polyoma virus; Hematopoietic cell transplantation; Hemorrhagic cystitis; INDUCED HEMORRHAGIC CYSTITIS; BONE-MARROW-TRANSPLANTATION; HYPERBARIC-OXYGEN THERAPY; NONCODING CONTROL REGION; LOW-DOSE CIDOFOVIR; JC-VIRUS; INTRAVESICULAR CIDOFOVIR; CLINICAL EFFECTIVENESS; VIDARABINE THERAPY; PEDIATRIC-PATIENTS;

D O I：

10.1016/j.jinf.2020.06.009

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

In hematopoietic cell transplantation (HCT) patients, BK polyomavirus (BKPyV) infection results in significant morbidity mainly due to hemorrhagic cystitis (HC). Despite increased knowledge acquired over recent decades, no treatment has shown effectiveness in the management of organ damage in HCT allografts. This review summarizes the current knowledge on BKPyV, from the virus constitution to the pathophysiology and immune-related mechanisms. We next focus on BKPyV-induced HC in HCT to discuss the benefit of monitoring BKPyV viruria and viremia in the management of patients. At last, we review currently used therapeutics, along with future promising therapies to propose clinical and practical guidelines and further interesting research areas. (C) 2020 The British Infection Association. Published by Elsevier Ltd. All rights reserved.

引用

页码：372 / 382

页数：11

共 123 条

[111] BK Virus Genotype Variance and Discordant BK Viremia PCR Assay Results [J].

Trofe-Clark, J. ;

Sparkes, T. ;

Gentile, C. ;

Van Deerlin, V. ;

Sawinski, D. ;

Bloom, R. D. .

AMERICAN JOURNAL OF TRANSPLANTATION, 2013, 13 (04) :1112-1113

[112] Brincidofovir (CMX001) Inhibits BK Polyomavirus Replication in Primary Human Urothelial Cells [J].

Tylden, Garth D. ;

Hirsch, Hans H. ;

Rinaldo, Christine Hanssen .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2015, 59 (06) :3306-3316

[113]

Tzannou I, 2017, J CLIN ONCOL, V35, P3547, DOI [10.1200/JCO.2017.73.0655, 10.1200/jco.2017.73.0655]

[114] The risk of polyomavirus BK-associated hemorrhagic cystitis after allogeneic hematopoietic SCT is associated with myeloablative conditioning, CMV viremia and severe acute GVHD [J].

Uhm, J. ;

Hamad, N. ;

Michelis, F. V. ;

Shanavas, M. ;

Kuruvilla, J. ;

Gupta, V. ;

Lipton, J. H. ;

Messner, H. A. ;

Seftel, M. ;

Kim, D. D. .

BONE MARROW TRANSPLANTATION, 2014, 49 (12) :1528-1534

[115] Sequential vidarabine infusion in the treatment of polyoma virus-associated acute haemorrhagic cystitis late after allogeneic bone marrow transplantation [J].

Vianelli, N ;

Renga, M ;

Azzi, A ;

De Santis, R ;

Bandini, G ;

Tosi, P ;

Tura, S .

BONE MARROW TRANSPLANTATION, 2000, 25 (03) :319-320

[116] Efficacy of Intravenous lmmunoglobulin in the Treatment of Persistent BK Viremia and BK Virus Nephropathy in Renal Transplant Recipients [J].

Vu, D. ;

Shah, T. ;

Ansari, J. ;

Naraghi, R. ;

Min, D. .

TRANSPLANTATION PROCEEDINGS, 2015, 47 (02) :394-398

[117] VIDARABINE - A PRELIMINARY REVIEW OF ITS PHARMACOLOGICAL PROPERTIES AND THERAPEUTIC USE [J].

WHITLEY, R ;

ALFORD, C ;

HESS, F ;

BUCHANAN, R .

DRUGS, 1980, 20 (04) :267-282

[118] Relationship of pretransplantation polyoma BK virus serologic findings and BK viral reactivation after hematopoietic stem cell transplantation [J].

Wong, Anders S. Y. ;

Chan, Kwok-Hung ;

Cheng, Vincent C. C. ;

Yuen, Kwok-Yung ;

Kwong, Yok-Lam ;

Leung, Anskar Y. H. .

CLINICAL INFECTIOUS DISEASES, 2007, 44 (06) :830-837

[119] SEQUENCE REARRANGEMENT IN JC VIRUS DNAS MOLECULARLY CLONED FROM IMMUNOSUPPRESSED RENAL-TRANSPLANT PATIENTS [J].

YOGO, Y ;

KITAMURA, T ;

SUGIMOTO, C ;

HARA, K ;

IIDA, T ;

TAGUCHI, F ;

TAJIMA, A ;

KAWABE, K ;

ASO, Y .

JOURNAL OF VIROLOGY, 1991, 65 (05) :2422-2428

[120] ISOLATION OF A POSSIBLE ARCHETYPAL-JC VIRUS-DNA SEQUENCE FROM NONIMMUNOCOMPROMISED INDIVIDUALS [J].

YOGO, Y ;

KITAMURA, T ;

SUGIMOTO, C ;

UEKI, T ;

ASO, Y ;

HARA, K ;

TAGUCHI, F .

JOURNAL OF VIROLOGY, 1990, 64 (06) :3139-3143

← 4 5 6 7 8 9 10 11 12 13 →