BK virus infection in allogeneic hematopoietic cell transplantation: An update on pathogenesis, immune responses, diagnosis and treatments

被引：21

作者：

Saade, Anastasia ^{[1
]}

Styczynski, Jan ^{[2
]}

Cesaro, Simone ^{[3
]}

机构：

[1] Ctr Hosp Univ Rennes, Dept Hematol, Ponchaillou, France

[2] Nicolaus Copernicus Univ Torun, Coll Med, Dept Pediat Hematol & Oncol, Bydgoszcz, Poland

[3] Azienda Osped Univ Integrata Verona, Pediat Hematol Oncol, Verona, Italy

来源：

JOURNAL OF INFECTION | 2020年 / 81卷 / 03期

关键词：

BK polyoma virus; Hematopoietic cell transplantation; Hemorrhagic cystitis; INDUCED HEMORRHAGIC CYSTITIS; BONE-MARROW-TRANSPLANTATION; HYPERBARIC-OXYGEN THERAPY; NONCODING CONTROL REGION; LOW-DOSE CIDOFOVIR; JC-VIRUS; INTRAVESICULAR CIDOFOVIR; CLINICAL EFFECTIVENESS; VIDARABINE THERAPY; PEDIATRIC-PATIENTS;

D O I：

10.1016/j.jinf.2020.06.009

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

In hematopoietic cell transplantation (HCT) patients, BK polyomavirus (BKPyV) infection results in significant morbidity mainly due to hemorrhagic cystitis (HC). Despite increased knowledge acquired over recent decades, no treatment has shown effectiveness in the management of organ damage in HCT allografts. This review summarizes the current knowledge on BKPyV, from the virus constitution to the pathophysiology and immune-related mechanisms. We next focus on BKPyV-induced HC in HCT to discuss the benefit of monitoring BKPyV viruria and viremia in the management of patients. At last, we review currently used therapeutics, along with future promising therapies to propose clinical and practical guidelines and further interesting research areas. (C) 2020 The British Infection Association. Published by Elsevier Ltd. All rights reserved.

引用

页码：372 / 382

页数：11

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