The effect of ivermectin on the viral load and culture viability in early treatment of nonhospitalized patients with mild COVID-19-a double-blind, randomized placebo-controlled trial
被引:13
作者:
Biber, Asaf
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Sheba Med Ctr, Ctr Geog Med & Trop Dis, Ramat Gan, Israel
Tel Aviv Univ, Sackler Fac Med, Tel Aviv, IsraelSheba Med Ctr, Ctr Geog Med & Trop Dis, Ramat Gan, Israel
Biber, Asaf
[1
,2
]
Harmelin, Geva
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Sheba Med Ctr, Emergency Med, Ramat Gan, IsraelSheba Med Ctr, Ctr Geog Med & Trop Dis, Ramat Gan, Israel
Harmelin, Geva
[3
]
Lev, Dana
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Sheba Med Ctr, Ctr Geog Med & Trop Dis, Ramat Gan, Israel
Tel Aviv Univ, Sackler Fac Med, Tel Aviv, IsraelSheba Med Ctr, Ctr Geog Med & Trop Dis, Ramat Gan, Israel
Lev, Dana
[1
,2
]
Ram, Li
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Sheba Med Ctr, Emergency Med, Ramat Gan, IsraelSheba Med Ctr, Ctr Geog Med & Trop Dis, Ramat Gan, Israel
Ram, Li
[3
]
Shaham, Amit
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Sheba Med Ctr, Emergency Med, Ramat Gan, IsraelSheba Med Ctr, Ctr Geog Med & Trop Dis, Ramat Gan, Israel
Shaham, Amit
[3
]
Nemet, Ital
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Minist Hlth, Cent Virol Lab, Ramat Gan, IsraelSheba Med Ctr, Ctr Geog Med & Trop Dis, Ramat Gan, Israel
Nemet, Ital
[4
]
Kliker, Limor
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Minist Hlth, Cent Virol Lab, Ramat Gan, IsraelSheba Med Ctr, Ctr Geog Med & Trop Dis, Ramat Gan, Israel
Kliker, Limor
[4
]
Erster, Oran
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Minist Hlth, Cent Virol Lab, Ramat Gan, IsraelSheba Med Ctr, Ctr Geog Med & Trop Dis, Ramat Gan, Israel
Erster, Oran
[4
]
Mandelboim, Michal
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Tel Aviv Univ, Sackler Fac Med, Tel Aviv, Israel
Minist Hlth, Cent Virol Lab, Ramat Gan, IsraelSheba Med Ctr, Ctr Geog Med & Trop Dis, Ramat Gan, Israel
Mandelboim, Michal
[2
,4
]
Schwartz, Eli
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Sheba Med Ctr, Ctr Geog Med & Trop Dis, Ramat Gan, Israel
Tel Aviv Univ, Sackler Fac Med, Tel Aviv, IsraelSheba Med Ctr, Ctr Geog Med & Trop Dis, Ramat Gan, Israel
Schwartz, Eli
[1
,2
]
机构:
[1] Sheba Med Ctr, Ctr Geog Med & Trop Dis, Ramat Gan, Israel
[2] Tel Aviv Univ, Sackler Fac Med, Tel Aviv, Israel
[3] Sheba Med Ctr, Emergency Med, Ramat Gan, Israel
[4] Minist Hlth, Cent Virol Lab, Ramat Gan, Israel
Objectives: Ivermectin, an antiparasitic agent, also has antiviral properties. In this study, we aimed to assess whether ivermectin has anti-SARS-CoV-2 activity. Methods: In this double-blinded trial, we compared patients receiving ivermectin for 3 days versus placebo in nonhospitalized adult patients with COVID-19. A reverse transcriptase-polymerase chain reaction from a nasopharyngeal swab was obtained at recruitment and every 2 days for at least 6 days. The primary endpoint was a reduction of viral load on the sixth day as reflected by cycle threshold level >30 (noninfectious level). The primary outcome was supported by the determination of viral-culture viability. Results: Of 867 patients screened, 89 were ultimately evaluated per-protocol (47 ivermectin and 42 placeboes). On day 6, the odds ratio (OR) was 2.62 (95% confidence interval [CI]: 1.09-6.31) in the ivermectin arm, reaching the endpoint. In a multivariable logistic regression model, the odds of a negative test on day 6 were 2.28 times higher in the ivermectin group but reached significance only on day 8 (OR 3.70; 95% CI: 1.19-11.49, P = 0.02). Culture viability on days 2 to 6 was positive in 13.0% (3/23) of ivermectin samples versus 48.2% (14/29) in the placebo group (P = 0.008). Conclusion: There were lower viral loads and less viable cultures in the ivermectin group, which shows its anti-SARS-CoV-2 activity. It could reduce transmission in these patients and encourage further studies with this drug. (c) 2022 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
机构:
IRCCS Casa Sollievo Sofferenza, Unit Pharm, Dept Pharmaceut, San Giovanni Rotondo, ItalyIRCCS Casa Sollievo Sofferenza, Unit Pharm, Dept Pharmaceut, San Giovanni Rotondo, Italy
Biancofiore, Annalucia
Mirijello, Antonio
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IRCCS Casa Sollievo Sofferenza, Unit Internal Med, Dept Med Sci, San Giovanni Rotondo, ItalyIRCCS Casa Sollievo Sofferenza, Unit Pharm, Dept Pharmaceut, San Giovanni Rotondo, Italy
Mirijello, Antonio
Puteo, Maria A.
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IRCCS Casa Sollievo Sofferenza, Unit Pharm, Dept Pharmaceut, San Giovanni Rotondo, ItalyIRCCS Casa Sollievo Sofferenza, Unit Pharm, Dept Pharmaceut, San Giovanni Rotondo, Italy
Puteo, Maria A.
Di Viesti, Maria P.
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IRCCS Casa Sollievo Sofferenza, Unit Pharm, Dept Pharmaceut, San Giovanni Rotondo, ItalyIRCCS Casa Sollievo Sofferenza, Unit Pharm, Dept Pharmaceut, San Giovanni Rotondo, Italy
Di Viesti, Maria P.
Labonia, Maria
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IRCCS Casa Sollievo Sofferenza, Unit Microbiol & Virol, Dept Diag & Care, San Giovanni Rotondo, ItalyIRCCS Casa Sollievo Sofferenza, Unit Pharm, Dept Pharmaceut, San Giovanni Rotondo, Italy
Labonia, Maria
Copetti, Massimiliano
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IRCCS Casa Sollievo Sofferenza, Unit Biostat, San Giovanni Rotondo, ItalyIRCCS Casa Sollievo Sofferenza, Unit Pharm, Dept Pharmaceut, San Giovanni Rotondo, Italy
Copetti, Massimiliano
De Cosmo, Salvatore
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IRCCS Casa Sollievo Sofferenza, Unit Internal Med, Dept Med Sci, San Giovanni Rotondo, ItalyIRCCS Casa Sollievo Sofferenza, Unit Pharm, Dept Pharmaceut, San Giovanni Rotondo, Italy
De Cosmo, Salvatore
Lombardi, Renato
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IRCCS Casa Sollievo Sofferenza, Unit Pharm, Dept Pharmaceut, San Giovanni Rotondo, ItalyIRCCS Casa Sollievo Sofferenza, Unit Pharm, Dept Pharmaceut, San Giovanni Rotondo, Italy
机构:
Royal Devon & Exeter NHS Fdn Trust, Exeter, Devon, EnglandPubl Hlth England, Natl Infect Serv, London, England
Poznalska, Gosia
Rodger, Alison
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Royal Free London NHS Fdn Trust, London, England
UCL London, Inst Global Hlth, London, EnglandPubl Hlth England, Natl Infect Serv, London, England
Rodger, Alison
Roberts, Stella
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Royal Devon & Exeter NHS Fdn Trust, Exeter, Devon, EnglandPubl Hlth England, Natl Infect Serv, London, England
Roberts, Stella
Rooney, Christopher
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Leeds Teaching Hosp NHS Trust, Leeds, W Yorkshire, England
Univ Leeds, Leeds, W Yorkshire, EnglandPubl Hlth England, Natl Infect Serv, London, England
Rooney, Christopher
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Wilcox, Mark
Warren, Simon
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Royal Free London NHS Fdn Trust, London, England
Royal Natl Orthopaed Hosp, Stanmore, Middx, EnglandPubl Hlth England, Natl Infect Serv, London, England
机构:
IRCCS Casa Sollievo Sofferenza, Unit Pharm, Dept Pharmaceut, San Giovanni Rotondo, ItalyIRCCS Casa Sollievo Sofferenza, Unit Pharm, Dept Pharmaceut, San Giovanni Rotondo, Italy
Biancofiore, Annalucia
Mirijello, Antonio
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机构:
IRCCS Casa Sollievo Sofferenza, Unit Internal Med, Dept Med Sci, San Giovanni Rotondo, ItalyIRCCS Casa Sollievo Sofferenza, Unit Pharm, Dept Pharmaceut, San Giovanni Rotondo, Italy
Mirijello, Antonio
Puteo, Maria A.
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机构:
IRCCS Casa Sollievo Sofferenza, Unit Pharm, Dept Pharmaceut, San Giovanni Rotondo, ItalyIRCCS Casa Sollievo Sofferenza, Unit Pharm, Dept Pharmaceut, San Giovanni Rotondo, Italy
Puteo, Maria A.
Di Viesti, Maria P.
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机构:
IRCCS Casa Sollievo Sofferenza, Unit Pharm, Dept Pharmaceut, San Giovanni Rotondo, ItalyIRCCS Casa Sollievo Sofferenza, Unit Pharm, Dept Pharmaceut, San Giovanni Rotondo, Italy
Di Viesti, Maria P.
Labonia, Maria
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机构:
IRCCS Casa Sollievo Sofferenza, Unit Microbiol & Virol, Dept Diag & Care, San Giovanni Rotondo, ItalyIRCCS Casa Sollievo Sofferenza, Unit Pharm, Dept Pharmaceut, San Giovanni Rotondo, Italy
Labonia, Maria
Copetti, Massimiliano
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h-index: 0
机构:
IRCCS Casa Sollievo Sofferenza, Unit Biostat, San Giovanni Rotondo, ItalyIRCCS Casa Sollievo Sofferenza, Unit Pharm, Dept Pharmaceut, San Giovanni Rotondo, Italy
Copetti, Massimiliano
De Cosmo, Salvatore
论文数: 0引用数: 0
h-index: 0
机构:
IRCCS Casa Sollievo Sofferenza, Unit Internal Med, Dept Med Sci, San Giovanni Rotondo, ItalyIRCCS Casa Sollievo Sofferenza, Unit Pharm, Dept Pharmaceut, San Giovanni Rotondo, Italy
De Cosmo, Salvatore
Lombardi, Renato
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h-index: 0
机构:
IRCCS Casa Sollievo Sofferenza, Unit Pharm, Dept Pharmaceut, San Giovanni Rotondo, ItalyIRCCS Casa Sollievo Sofferenza, Unit Pharm, Dept Pharmaceut, San Giovanni Rotondo, Italy
机构:
Royal Devon & Exeter NHS Fdn Trust, Exeter, Devon, EnglandPubl Hlth England, Natl Infect Serv, London, England
Poznalska, Gosia
Rodger, Alison
论文数: 0引用数: 0
h-index: 0
机构:
Royal Free London NHS Fdn Trust, London, England
UCL London, Inst Global Hlth, London, EnglandPubl Hlth England, Natl Infect Serv, London, England
Rodger, Alison
Roberts, Stella
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h-index: 0
机构:
Royal Devon & Exeter NHS Fdn Trust, Exeter, Devon, EnglandPubl Hlth England, Natl Infect Serv, London, England
Roberts, Stella
Rooney, Christopher
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机构:
Leeds Teaching Hosp NHS Trust, Leeds, W Yorkshire, England
Univ Leeds, Leeds, W Yorkshire, EnglandPubl Hlth England, Natl Infect Serv, London, England
Rooney, Christopher
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Wilcox, Mark
Warren, Simon
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机构:
Royal Free London NHS Fdn Trust, London, England
Royal Natl Orthopaed Hosp, Stanmore, Middx, EnglandPubl Hlth England, Natl Infect Serv, London, England