Newcastle Disease Virus as a Vaccine Vector for SARS-CoV-2

被引:16
作者
Shirvani, Edris [1 ]
Samal, Siba K. [1 ]
机构
[1] Univ Maryland, Virginia Maryland Coll Vet Med, College Pk, MD 20742 USA
关键词
SARS-CoV-2; COVID-19; coronavirus; Newcastle disease virus (NDV); vaccine; viral vector and viral respiratory infection; FOREIGN GENE; NEUTRALIZING ANTIBODIES; HIGH-LEVEL; IMMUNIZATION; EXPRESSION; STRAIN; CANDIDATE; INSERTION; PRIMATES; SEQUENCE;
D O I
10.3390/pathogens9080619
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in more than 16 million infections and more than 600,000 deaths worldwide. There is an urgent need to develop a safe and effective vaccine against SARS-CoV-2. Currently, several strategies are being pursued to develop a safe and effective SARS-CoV-2 vaccine. However, each vaccine strategy has distinct advantages and disadvantages. Therefore, it is important to evaluate multiple vaccine platforms to select the most efficient vaccine platform for SARS-CoV-2. In this regard, Newcastle disease virus (NDV), an avian virus, has several well-suited properties for development of a vector vaccine against SARS-CoV-2. Here, we elaborate on the idea of considering NDV as a vaccine vector for SARS-CoV-2.
引用
收藏
页码:1 / 8
页数:8
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