Newcastle Disease Virus as a Vaccine Vector for SARS-CoV-2

被引：16

作者：

Shirvani, Edris ^{[1
]}

Samal, Siba K. ^{[1
]}

机构：

[1] Univ Maryland, Virginia Maryland Coll Vet Med, College Pk, MD 20742 USA

来源：

PATHOGENS | 2020年 / 9卷 / 08期

关键词：

SARS-CoV-2; COVID-19; coronavirus; Newcastle disease virus (NDV); vaccine; viral vector and viral respiratory infection; FOREIGN GENE; NEUTRALIZING ANTIBODIES; HIGH-LEVEL; IMMUNIZATION; EXPRESSION; STRAIN; CANDIDATE; INSERTION; PRIMATES; SEQUENCE;

D O I：

10.3390/pathogens9080619

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in more than 16 million infections and more than 600,000 deaths worldwide. There is an urgent need to develop a safe and effective vaccine against SARS-CoV-2. Currently, several strategies are being pursued to develop a safe and effective SARS-CoV-2 vaccine. However, each vaccine strategy has distinct advantages and disadvantages. Therefore, it is important to evaluate multiple vaccine platforms to select the most efficient vaccine platform for SARS-CoV-2. In this regard, Newcastle disease virus (NDV), an avian virus, has several well-suited properties for development of a vector vaccine against SARS-CoV-2. Here, we elaborate on the idea of considering NDV as a vaccine vector for SARS-CoV-2.

引用

页码：1 / 8

页数：8

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