Increased Program Cell Death-1 Expression on T Lymphocytes of Patients With Progressive Multifocal Leukoencephalopathy

被引：69

作者：

Tan, Chen Sabrina ^{[1
,2
,3
]}

Bord, Evelyn ^{[2
,3
]}

Broge, Thomas A., Jr. ^{[2
,3
]}

Glotzbecker, Brett ^{[4
,5
]}

Mills, Heidi ^{[4
,5
]}

Gheuens, Sarah ^{[2
,3
]}

Rosenblatt, Jacalyn ^{[4
,5
]}

Avigan, David ^{[4
,5
]}

Koralnik, Igor J. ^{[2
,3
]}

机构：

[1] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Dept Med,Div Infect Dis, Boston, MA 02215 USA

[2] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Dept Med,Div Viral Pathogenesis, Boston, MA 02215 USA

[3] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Dept Neurol,Div Neurovirol, Boston, MA 02215 USA

[4] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Dept Med,Div Hematol Oncol, Boston, MA 02215 USA

[5] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Dept Med,Div Vaccine Res, Boston, MA 02215 USA

来源：

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES | 2012年 / 60卷 / 03期

关键词：

PML; PD-1; immune exhaustion; immunotherapy; C VIRUS-INFECTION; JC VIRUS; SYNDROME AIDS; PD-1; NEUROPATHOLOGY; BLOCKADE; IMMUNITY; CD4(+);

D O I：

10.1097/QAI.0b013e31825a313c

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The cellullar immune response is important in the containment of progressive multifocal leukoencephalopathy (PML). We examined program cell death-1 (PD-1) expression, a marker of cellular immune exhaustion, on T lymphocytes in PML. PD-1 expression was elevated on total CD4(+) and CD8(+) T cells (medians 36% and 24%) in PML patients compared with healthy control subjects (medians 14% and 18%; P = 0.0015 and P = 0.033). In PML patients, JC virus (JCV)-specific CD8(+) cytotoxic T lymphocytes expressed PD-1 more frequently than total CD8(+) T lymphocytes (means 39% and 78%, P = 0.0004). Blocking the PD-1 receptor increased JCV-specific T-cell immune response in a subgroup of PML patients.

引用

页码：244 / 248

页数：5

共 17 条

[1] Restoring function in exhausted CD8 T cells during chronic viral infection [J].