Vitreomacular Adhesion and Neovascular Age-Related Macular Degeneration

被引:67
|
作者
Simpson, Andrew R. H.
Petrarca, Robert
Jackson, Timothy L. [1 ]
机构
[1] Kings Coll Hosp London, Dept Ophthalmol, London SE5 9RS, England
关键词
age-related macular degeneration; vitreomacular adhesion; vitreomactilar traction; vitreous; OPTICAL COHERENCE TOMOGRAPHY; ENDOTHELIAL GROWTH-FACTOR; POSTERIOR VITREOUS DETACHMENT; RETINAL-PIGMENT EPITHELIUM; VITREORETINAL INTERFACE; CHOROIDAL NEOVASCULARIZATION; PHARMACOLOGICAL VITREOLYSIS; PLASMINOGEN-ACTIVATOR; DIABETIC-RETINOPATHY; ASSISTED VITRECTOMY;
D O I
10.1016/j.survophthal.2012.01.011
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
We explore the hypothesis that vitreomacular adhesion (VMA) and vitreomacular traction (VMT) play a role in the pathogenesis and clinical course of neovascular ("wet") age-related macular degeneration (AMD). Several biological theories are offered to explain this possible association, including direct tractional force, altered vitreous oxygenation, altered diffusion coefficients of intravitreal molecules, and alterations in the pharmacokinetics of intravitreal drugs. Release of VMT may improve the clinical course of neovascular AMD, and a few case series suggest that vitrectomy can lead to both a functional and anatomic improvement. A large, randomized, controlled clinical trial is underway, investigating pharmacologic release of VMA in eyes with neovascular AMD. (Surv Ophthalmol 57:498-509, 2012. (c) 2012 Elsevier Inc. All rights reserved.)
引用
收藏
页码:498 / 509
页数:12
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