Synthesis of 3-(2, 8, 9-trioxa-5-aza-1-germatricyclo [3.3.3.0] Undecane-1-yl)-3-(4-hydroxyl-3-methoxyphenyl)-propionic Acid and its Inhibitory Effect on the Cervical Tumor U14 in vitro and in vivo

In this study, the novel germatrane compound, 3-(2, 8, 9-trioxa-5-aza-1-germatricyclo [3.3.3.0] undecane-1-yl)-3-(4-hydroxy-3-methoxyphenyl)-propionic acid (1), has been synthesized and its activities against cervical tumor U14 were evaluated in vitro and in vivo. The results have demonstrated that the compound posed significant inhibition on U14 tumor with IC50 values of 48.57 mg/L in cell-based assay and tumor inhibitory rates of 38.50 %, 47.17 % and 64.02 % (from low dose to high dose) in animal experiment.