Synthesis of oligosaccharides of genistein and quercetin as potential anti-inflammatory agents

被引：17

作者：

Shimoda, Kei ^{[1
]}

Kobayashi, Tatsunari ^{[2
]}

Akagi, Masaaki ^{[3
]}

Hamada, Hatsuyuki ^{[4
]}

Hamada, Hiroki ^{[2
]}

机构：

[1] Oita Univ, Fac Med, Dept Pharmacol & Therapeut, Oita 8795593, Japan

[2] Okayama Univ Sci, Fac Sci, Dept Life Sci, Okayama 7000005, Japan

[3] Tokushima Bunri Univ, Fac Pharmaceut Sci, Dept Pharmacol, Yamashiro, Tokushima 7708514, Japan

[4] Natl Inst Fitness & Sports Kanoya, Kagoshima 8912390, Japan

来源：

CHEMISTRY LETTERS | 2008年 / 37卷 / 08期

关键词：

D O I：

10.1246/cl.2008.876

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Genistein was glucosylated to its 7-O-beta-D-glucoside by cultured cells of Ipomoea batatas, while Cultured Marchantia polymorpha cells produced 4'-O-beta-D-glucoside and 7-O-beta-D-glucoside of genistein. On the other hand, quercetin was converted into its 3-O-beta-D-glucoside by I. batatas, and M. polymorpha gave 3-O-beta-D-glucoside and 7-O-beta-D-glucoside of quercetin. These four glucosides were further glycosylated to the corresponding beta-maltosides and beta-maltotriosides by cyclodextrin glucanotransferase. Genistein 7-O-beta-maltooligosaccharides, quercetin 3-O-beta-glucoside. and quercetin 7-O-beta-maltooligosaccharides showed potent inhibitory effects on histamine release from rat peritoneal mast cells.

引用

页码：876 / 877

页数：2

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