A gravity-based three-dimensional compass in the mouse brain

被引：28

作者：

Angelaki, Dora E. ^{[1
,2
,3
]}

Ng, Julia ^{[3
]}

Abrego, Amada M. ^{[3
]}

Cham, Henry X. ^{[3
]}

Asprodini, Eftihia K. ^{[4
]}

Dickman, J. David ^{[3
,5
]}

Laurens, Jean ^{[3
]}

机构：

[1] NYU, Ctr Neural Sci, New York, NY 10003 USA

[2] NYU, Tandon Sch Engn, New York, NY 10003 USA

[3] Baylor Coll Med, Dept Neurosci, Houston, TX 77030 USA

[4] Univ Thessaly, Fac Med, Sch Hlth Sci, Dept Pharmacol, Larisa, Greece

[5] Rice Univ, Dept Elect & Comp Engn, POB 1892, Houston, TX 77251 USA

来源：

NATURE COMMUNICATIONS | 2020年 / 11卷 / 01期

关键词：

HEAD-DIRECTION SIGNAL; REPRESENTATION; ORIENTATION; ANTERODORSAL; LOCOMOTION; MOVEMENT; ORIGINS; CORTEX; CELLS; MODEL;

D O I：

10.1038/s41467-020-15566-5

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Gravity sensing provides a robust verticality signal for three-dimensional navigation. Head direction cells in the mammalian limbic system implement an allocentric neuronal compass. Here we show that head-direction cells in the rodent thalamus, retrosplenial cortex and cingulum fiber bundle are tuned to conjunctive combinations of azimuth and tilt, i.e. pitch or roll. Pitch and roll orientation tuning is anchored to gravity and independent of visual landmarks. When the head tilts, azimuth tuning is affixed to the head-horizontal plane, but also uses gravity to remain anchored to the allocentric bearings in the earth-horizontal plane. Collectively, these results demonstrate that a three-dimensional, gravity-based, neural compass is likely a ubiquitous property of mammalian species, including ground-dwelling animals.

引用

页数：13

共 58 条

[1] Egocentric boundary vector tuning of the retrosplenial cortex [J].