Sex biology contributions to vulnerability to Alzheimer's disease: A think tank convened by the Women's Alzheimer's Research Initiative

被引：187

作者：

Snyder, Heather M. ^{[1
]}

Asthana, Sanjay ^{[2
]}

Bain, Lisa

Brinton, Roberta ^{[3
,4
,5
]}

Craft, Suzanne ^{[6
]}

Dubal, Dena B. ^{[7
]}

Espeland, Mark A. ^{[8
]}

Gatz, Margaret ^{[9
]}

Mielke, Michelle M. ^{[10
]}

Raber, Jacob ^{[11
,12
,13
]}

Rapp, Peter R. ^{[14
]}

Yaffe, Kristine ^{[7
,15
]}

Carrillo, Maria C. ^{[1
]}

机构：

[1] Alzheimers Assoc, Div Med & Sci Relat, Chicago, IL USA

[2] Univ Wisconsin, Sch Med, Dept Med, Madison, WI USA

[3] Univ Southern Calif, Dept Pharmacol & Pharmaceut Sci, Los Angeles, CA USA

[4] Univ Southern Calif, Dept Biomed Engn, Los Angeles, CA USA

[5] Univ Southern Calif, Dept Neurol, Los Angeles, CA USA

[6] Wake Forest Sch Med, Dept Med, Winston Salem, NC USA

[7] Univ Calif San Francisco, Dept Neurol, San Francisco, CA USA

[8] Wake Forest Sch Med, Dept Biostat Sci, Winston Salem, NC USA

[9] Univ Southern Calif, Dept Psychol, Los Angeles, CA USA

[10] Mayo Clin, Dept Hlth Sci Res & Neurol, Div Epidemiol, Rochester, MN USA

[11] Oregon Hlth & Sci Univ, Dept Behav Neurosci, Dept Neurol, Portland, OR 97201 USA

[12] Oregon Hlth & Sci Univ, Dept Radiat Med, Portland, OR 97201 USA

[13] Oregon Hlth & Sci Univ, ONPRC, Div Neurosci, Portland, OR 97201 USA

[14] NIA, Lab Behav Neurosci, Neurocognit Aging Sect, Intramural Res Program, Baltimore, MD 21224 USA

[15] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA 94143 USA

来源：

ALZHEIMERS & DEMENTIA | 2016年 / 12卷 / 11期

关键词：

Alzheimer's disease; Neurodegeneration; Risk factors; Women; Sex biology; Estrogen; Hormones; APOE; POSTMENOPAUSAL HORMONE-THERAPY; MILD COGNITIVE IMPAIRMENT; CONJUGATED EQUINE ESTROGENS; REGIONAL BRAIN VOLUMES; APOLIPOPROTEIN-E; AMYLOID-BETA; INTRANASAL INSULIN; METABOLIC SYNDROME; OLDER-ADULTS; DEPRESSIVE SYMPTOMS;

D O I：

10.1016/j.jalz.2016.08.004

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

More than 5 million Americans are living with Alzheimer's disease (AD) today, and nearly two-thirds of Americans with AD are women. This sex difference may be due to the higher longevity women generally experience; however, increasing evidence suggests that longevity alone is not a sufficient explanation and there may be other factors at play. The Alzheimer's Association convened an expert think tank to focus on the state of the science and level of evidence around gender and biological sex differences for AD, including the knowledge gaps and areas of science that need to be more fully addressed. This article summarizes the think tank discussion, moving forward a research agenda and funding program to better understand the biological underpinnings of sex- and gender-related disparities of risk for AD. (C) 2016 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.

引用

页码：1186 / 1196

页数：11

共 125 条

[1] Selective androgen receptor modulators antagonize apolipoprotein E4-induced cognitive impairments [J].

Acevedo, Summer ;

Gardell, Luis ;

Bradley, Stefania Risso ;

Piu, Fabrice ;

Raber, Jacob .

LETTERS IN DRUG DESIGN & DISCOVERY, 2008, 5 (04) :271-276

[2] Sex Modifies the APOE-Related Risk of Developing Alzheimer Disease [J].

Altmann, Andre ;

Tian, Lu ;

Henderson, Victor W. ;

Greicius, Michael D. .

ANNALS OF NEUROLOGY, 2014, 75 (04) :563-573

[3]

Alzheimer's A, 2014, ALZHEIMERS DEMENT, V2014, pe47, DOI [DOI 10.1016/J.JALZ.2010.01.009, DOI 10.1016/J.JALZ.2015.02.003]

[4] INCIDENCE OF DEMENTIA AND PROBABLE ALZHEIMERS-DISEASE IN A GENERAL-POPULATION - THE FRAMINGHAM-STUDY [J].

BACHMAN, DL ;

WOLF, PA ;

LINN, RT ;

KNOEFEL, JE ;

COBB, JL ;

BELANGER, AJ ;

WHITE, LR ;

DAGOSTINO, RB .

NEUROLOGY, 1993, 43 (03) :515-519

[5] Insulin Resistance and Alzheimer-like Reductions in Regional Cerebral Glucose Metabolism for Cognitively Normal Adults With Prediabetes or Early Type 2 Diabetes [J].

Baker, Laura D. ;

Cross, Donna J. ;

Minoshima, Satoshi ;

Belongia, Dana ;

Watson, Stennis ;

Craft, Suzanne .

ARCHIVES OF NEUROLOGY, 2011, 68 (01) :51-57

[6] Cognitive response to estradiol in postmenopausal women is modified by high cortisol [J].

Baker, Laura D. ;

Asthana, Sanjay ;

Cholerton, Brenna A. ;

Wilkinson, Charles W. ;

Plymate, Stephen R. ;

Green, Pattie S. ;

Merriam, George R. ;

Fishel, Mark A. ;

Watson, G. Stennis ;

Cherrier, Monique M. ;

Kletke, Monica L. ;

Mehta, Pankaj D. ;

Craft, Suzanne .

NEUROBIOLOGY OF AGING, 2012, 33 (04) :829.e9-829.e20

[7] Aerobic Exercise Improves Cognition for Older Adults with Glucose Intolerance, A Risk Factor for Alzheimer's Disease [J].

Baker, Laura D. ;

Frank, Laura L. ;

Foster-Schubert, Karen ;

Green, Pattie S. ;

Wilkinson, Charles W. ;

McTiernan, Anne ;

Cholerton, Brenna A. ;

Plymate, Stephen R. ;

Fishel, Mark A. ;

Watson, G. Stennis ;

Duncan, Glen E. ;

Mehta, Pankaj D. ;

Craft, Suzanne .

JOURNAL OF ALZHEIMERS DISEASE, 2010, 22 (02) :569-579

[8]

Barron Anna M, 2012, Front Biosci (Elite Ed), V4, P976, DOI 10.2741/E434

[9] Estrogen deficiency leads to telomerase inhibition, telomere shortening and reduced cell proliferation in the adrenal gland of mice [J].

Bayne, Sharyn ;

Jones, Margaret E. E. ;

Li, He ;

Pinto, Alex R. ;

Simpson, Evan R. ;

Liu, Jun-Ping .

CELL RESEARCH, 2008, 18 (11) :1141-1150

[10] Differential sensitivity of men and women to anorexigenic and memory-improving effects of intranasal insulin [J].

Benedict, Christian ;

Kern, Werner ;

Schultes, Bernd ;

Born, Jan ;

Hallschmid, Manfred .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2008, 93 (04) :1339-1344

← 1 2 3 4 5 6 7 8 9 10 →