Comparative study of catalytic (DNA-hydrolyzing) and cytotoxic properties of anti-DNA autoantibodies

被引：4

作者：

Suchkov, SV ^{[1
]}

机构：

[1] Moscow Reg Res & Clin Inst, Clin Immunol Lab, Moscow, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2001年 / 131卷 / 04期

关键词：

DNA abzymes; anti-DNA autoantibodies; cytotoxicity; autoimmune mice; systemic lupus erythematosus;

D O I：

10.1023/A:1017904219726

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

DNA-hydrolyzing and cytotoxic properties of anti-DNA autoantibodies isolated from patients with systemic autoimmune diseases and from autoimmune MRL-1pr/1pr, SJL/J, and (NZBx NZW)F-1 mice were studied. Cytotoxic and catalytic properties of these antibodies correlated. A relationship between the stage of systemic lupus erythematosus and catalytic and cytotoxic properties of DNA abzymes was revealed. Of all studied cells, L929 cells were most sensitive were most sensitive to in vitro effect of antibodies. Treatment of target cells with anti-DNA autoantibodies with cytotoxic properties induced internucleosomal DNA fragmentation, which is characteristic of apoptosis.

引用

页码：353 / 355

页数：3

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