Glucocorticoid resistance in paediatric acute lymphoblastic leukaemia

被引：45
|
作者：
Bhadri, Vivek A. [1 ,2 ]
Trahair, Toby N. [2 ]
Lock, Richard B.
机构：
[1] Univ New S Wales, Lowy Canc Res Ctr, Childrens Canc Inst Australia Med Res, Randwick, NSW 2031, Australia
[2] Univ New S Wales, Sydney Childrens Hosp, Ctr Childrens Canc & Blood Disorders, Randwick, NSW 2031, Australia
来源：
JOURNAL OF PAEDIATRICS AND CHILD HEALTH | 2012年 / 48卷 / 08期
基金：
英国医学研究理事会;
关键词：
glucocorticoid; haematology; leukaemia; oncology; GAMMA-SECRETASE INHIBITORS; MESSENGER-RNA EXPRESSION; INDUCED APOPTOSIS; BH3-ONLY PROTEINS; CELL-DEATH; RECEPTOR-ALPHA; CHILDHOOD; THERAPY; GENE; DEXAMETHASONE;
D O I：
10.1111/j.1440-1754.2011.02212.x
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
Glucocorticoids (GCs), such as prednisolone and dexamethasone, are key components in multi-agent chemotherapy protocols used for the treatment of acute lymphoblastic leukaemia (ALL). Approximately 10% of children with ALL will respond poorly to GCs, and GC resistance is associated with a significantly inferior outcome. This review summarises the current knowledge of GC resistance in ALL, including the roles of the GC receptor and its co-chaperone molecules, the pro-apoptotic and pro-survival B-cell lymphoma 2 family members and alternative non-apoptotic mechanisms of cell death. It concludes with a discussion on therapeutic attempts to overcome GC resistance.
引用
收藏
页码：634 / 640
页数：7
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