Azole-Resistant COVID-19-Associated Pulmonary Aspergillosis in an Immunocompetent Host: A Case Report

被引：88

作者：

Meijer, Eelco F. J. ^{[1
,2
,3
]}

Dofferhoff, Anton S. M. ^{[3
,4
]}

Hoiting, Oscar ^{[5
]}

Buil, Jochem B. ^{[1
,2
]}

Meis, Jacques F. ^{[1
,2
,3
,6
]}

机构：

[1] Radboud Univ Nijmegen, Dept Med Microbiol, Med Ctr, NL-6500 HB Nijmegen, Netherlands

[2] Ctr Expertise Mycol Radboudumc CWZ, NL-6532 SZ Nijmegen, Netherlands

[3] Canisius Wilhelmina Hosp CWZ, Dept Med Microbiol & Infect Dis, NL-6532 SZ Nijmegen, Netherlands

[4] Canisius Wilhelmina Hosp CWZ, Dept Internal Med, NL-6532 SZ Nijmegen, Netherlands

[5] Canisius Wilhelmina Hosp CWZ, Dept Intens Care Med, NL-6532 SZ Nijmegen, Netherlands

[6] Univ Fed Parana, Bioproc Engn & Biotechnol Grad Program, BR-81531970 Curitiba, Parana, Brazil

来源：

JOURNAL OF FUNGI | 2020年 / 6卷 / 02期

关键词：

SARS-CoV-2; co-infection; pulmonary aspergillosis; ICU; azole-resistantAspergillus; Aspergillus fumigatus; CAPA; TR(34)L98H; BRONCHOALVEOLAR LAVAGE FLUID; CRITICALLY-ILL PATIENTS; LATERAL-FLOW DEVICE; BETA-D-GLUCAN; FUNGAL DISEASES; GALACTOMANNAN; DIAGNOSIS; FUMIGATUS;

D O I：

10.3390/jof6020079

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

COVID-19-associated pulmonary aspergillosis (CAPA) is a recently described disease entity affecting patients with severe pulmonary abnormalities treated in intensive care units. Delays in diagnosis contribute to a delayed start of antifungal therapy. In addition, the emergence of resistance to triazole antifungal agents puts emphasis on early surveillance for azole-resistantAspergillusspecies. We present a patient with putative CAPA due toAspergillus fumigatuswith identification of a triazole-resistant isolate during therapy. We underline the challenges faced in the management of these cases, the importance of early diagnosis and need for surveillance given the emergence of triazole resistance.

引用

页码：1 / 8

页数：8

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