Synthesis using microwave irradiation, characterisation and antibacterial activity of novel deoxycholic acid-triazole conjugates

被引：5

作者：

Yang, Jie ^{[1
]}

Zhao, Zhigang ^{[1
]}

Li, Hui ^{[1
]}

机构：

[1] SW Univ Nationalities, Coll Chem & Environm Protect Engn, Chengdu 610041, Peoples R China

来源：

JOURNAL OF CHEMICAL RESEARCH | 2012年 / 07期

关键词：

deoxycholic acid; triazole; microwave irradiation; antibacterial activity; ANTIMICROBIAL ACTIVITY; BILE; DERIVATIVES; DESIGN;

D O I：

10.3184/174751912X13364636691591

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Novel deoxycholic acid 3 alpha-triazole conjugates based on methyl 3 alpha-chloroacetoxy-12 alpha-hydroxy-cholanate have been synthesised. The synthesis is accelerated by microwave irradiation under solvent free conditions in the presence of K2CO3. Some of these compounds were tested for antibacterial activity against B. subtilis, P. aeruginosa and S. aureus. The preliminary results indicated that these deoxycholic acid-triazole conjugates have good inhibitory effect against B. subtilis. All of the compounds were characterised by H-1 NMR, IR, ESI-MS spectra and elemental analyses.

引用

页码：383 / 386

页数：4

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