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THE CONCISE GUIDE TO PHARMACOLOGY 2013/14: CATALYTIC RECEPTORS
被引:142
作者:
Alexander, Stephen P. H.
[1
]
Benson, Helen E.
[2
]
Faccenda, Elena
[2
]
Pawson, Adam J.
[2
]
Sharman, Joanna L.
[2
]
Spedding, Michael
[3
]
Peters, John A.
[4
]
Harmar, Anthony J.
[2
]
机构:
[1] Univ Nottingham, Sch Med, Sch Life Sci, Nottingham NG7 2UH, England
[2] Univ Edinburgh, Univ BHF Ctr Cardiovasc Sci, Edinburgh EH16 4TJ, Midlothian, Scotland
[3] Spedding Res Solut SARL, F-78110 Le Vesinet, France
[4] Univ Dundee, Ninewells Hosp & Med Sch, Med Educ Inst, Div Neurosci, Dundee DD1 9SY, Scotland
基金:
英国惠康基金;
关键词:
ATRIAL-NATRIURETIC-PEPTIDE;
SMALL-MOLECULE INHIBITORS;
TYROSINE KINASE INHIBITORS;
GROWTH-FACTOR;
TGF-BETA;
SIGNAL-TRANSDUCTION;
CLEARANCE RECEPTOR;
IN-VIVO;
BIOLOGICAL EVALUATION;
IMMUNE-RESPONSE;
D O I:
10.1111/bph.12449
中图分类号:
R9 [药学];
学科分类号:
1007 ;
摘要:
The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of the key properties of over 2000 human drug targets with their pharmacology, plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. The full contents can be found at http://onlinelibrary.wiley. com/doi/10.1111/bph.12444/full. Catalytic receptors are one of the seven major pharmacological targets into which the Guide is divided, with the others being G protein-coupled receptors, ligand-gated ion channels, ion channels, nuclear hormone receptors, transporters and enzymes. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. A new landscape format has easy to use tables comparing related targets. It is a condensed version of material contemporary to late 2013, which is presented in greater detail and constantly updated on the website www.guidetopharmacology.org, superseding data presented in previous Guides to Receptors and Channels. It is produced in conjunction with NC-IUPHAR and provides the official IUPHAR classification and nomenclature for human drug targets, where appropriate. It consolidates information previously curated and displayed separately in IUPHAR-DB and the Guide to Receptors and Channels, providing a permanent, citable, point-in-time record that will survive database updates. Copyright © 2013 The British Pharmacological Society.
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页码:1676 / 1705
页数:30
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